Wojciech Łuniewski

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In this paper, the decomposition of imatinib mesylate (ImM) under hydrolytic (neutral, acidic, alkaline), oxidative and photolytic conditions was studied. The imatinib mesylate is practically photostable and stable under neutral conditions. The main degradation products under acidic and alkaline conditions are compounds:(More)
An HPLC method for determination of related substances in temozolomide drug substance was developed. Particular attention was paid to the stability studies due to the fact that temozolomide is unstable in a solution and quickly decomposes to its main degradation product 5-amino-4-imidazolecarboxamide (AIC). A mixture of diluted acetic acid and acetonitrile(More)
In this article the crystal structures of the starting material TZ-5 and the key intermediate TZ-6 of temozolomide (TZ-7), an anticancer therapeutic agent, are presented, together with their spectroscopic and thermal characteristics. Both compounds crystallize in the triclinic P-1 space group. X-ray crystallography studies proved that the compound TZ-6(More)
Bosentan monohydrate (4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl) pyrimidin-4-yl]benzene-1-sulfonamide monohydrate) is a dual endothelin receptor antagonist (ERA) applied in the treatment of pulmonary arterial hypertension. To achieve effective process control of the bosentan monohydrate synthesis, it was necessary to develop(More)
Tumors that are Her-2-positive tend to grow and spread more quickly than other types of breast cancer. Overexpression of Her-2 can be a predictive biomarker for stratification of patients for therapy with Herceptin (containing humanized IgG1 monoclonal antibody trastuzumab) or Tykerb (containing lapatinib di-p-toluenesulfonate) drug. Usually, Her-2 status(More)
Bosentan is an active substance in the orphan drugs used to treat pulmonary artery hypertension (PAH). It is a dual endothelin receptor antagonist (ERA) with the affinity for both receptors of the A and B: endothelin-A (ETA) and endothelin-B (ETB). Under normal conditions, ETA or ETB receptors cause constrictions of the pulmonary blood vessels. By blocking(More)
Chemistry Dept., Pharmaceutical Research Institute, Rydygiera St. 8, 01-793 Warszawa; Faculty of Biotechnology, Wrocław University, Fryderyk Joliot-Curie St. 14a, 50-383 Wrocław; Faculty of Chemistry, Wroclaw University of Technology, C.K. Norwid St.4/6, 50373 Wrocław; Experimental Acticancer Therapy Laboratory, Institute of Immunology and Experimental(More)
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