Wm. Joshua Russell

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Glomerulopathic monoclonal light chains (G-LC) interact with mesangial cells (MC), resulting in alterations of mesangial homeostasis. Early signaling events control mitogenic activities and cytokine production, which in turn participate in the subsequent pathologic events. Mesangial homeostasis is affected in two very different ways, depending on whether(More)
We have shown in vitro AL-amyloid formation by human mesangial cells (HMCs). AL-amyloid formation may require lysosomal processing of the light chains (LCs) by HMCs for amyloidogenesis to occur. Chloroquine inhibits lysosomal activity. TGF-beta mediates extracellular matrix formation in many glomerulopathies. Thrombospondin (TSP) has been proposed as a(More)
This paper addresses the problem of estimating the states of a group of agents from noisy measurements of pairwise differences between agents' states. The agents can be viewed as nodes in a graph and the relative measurements between agents as the graph's edges. We propose a new distributed algorithm that exploits the existence of cycles in the graph to(More)
We consider the problem of estimating the locations of mobile agents by fusing the measurements of displacements of the agents as well as relative position measurements between pairs of agents. We propose an algorithm that computes an approximation of the centralized optimal (Kalman filter) estimates. The algorithm is distributed in the sense each agent can(More)
We address the problem of estimating the state of a multi-agent system based on measurements corrupted by impulsive noise and whose dynamics are subject to impulsive disturbances. The qualifier " impulsive " refers to the fact that noise and disturbances are relatively small most of the time, but occasionally take large values. Noise and disturbances are(More)
Glomerulopathic light chains (LCs) are associated with two distinct mesangiopathies: AL (light-chain-related) amyloidosis and light-chain deposition disease (LCDD) with immunomorphologic features that are well documented in the literature. Even though both conditions are caused by monoclonal LCs, these entities differ dramatically in their morphologic(More)
Bacterial extracts prepared by ultrasonic disruption were reacted with both narrow- and broad-spectrum reference (homologous) and cross-reacting (heterologous) precipitins produced in rabbits. Quantitation of the reaction was obtained by densitometry of the antigen-antibody interface. Comparisons were made of sonic extracts from various starting populations(More)