Witold Lukas

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BACKGROUND Bacterial and viral respiratory tract infections may trigger relapses in patients with PR3-positive vasculitis. Data have suggested that treatment with co-trimoxazole may be beneficial, because this antibiotic could act by eliminating the offending microbe and thereby stopping the initiating stimulus. GOAL AND METHODS Prospective, randomized,(More)
BACKGROUND Excessive body weight is known to cluster with cardiovascular (CV) risk factors, but it is not clear which anthropometric obesity measure provides best independent predictive value of coronary artery disease (CAD). METHODS AND RESULTS We explored associations between CAD and four different obesity measures (body mass index (BMI), waist(More)
In a preliminary study the levels of four non-planar polychlorinated biphenyls congeners (118, 138, 153 and 180), and of the toxic metals lead and cadmium, and their antagonist selenium and zinc were measured in cord blood from apparently healthy neonates from the region of Prague and Upper Silezia (Katowice). These "background" levels were compared with(More)
AIMS To determine: (1) achievement of cholesterol therapy goals in patients receiving lipid-lowering drugs in Polish primary care between the years 2004 and 2006; (2) the characteristics of patients that are associated with attainment of these goals. DESIGN Cross-sectional study in randomly selected Polish primary care practices. METHOD 5248 patients(More)
OBJECTIVE Visfatin (VISF) is a recently described peptide regulating the process of adipocyte differentiation. Only one pilot study of VISF expression in the fat tissue and its circulating concentrations in a small group of patients with anorexia nervosa (AN) have been published, yet. DESIGN AND PATIENTS Cross-sectional assessment of VISF serum(More)
OBJECTIVE The impact of fast changes in obesity indices on other measures of metabolic health is poorly defined in the general population. Using the Polish accession to the European Union as a model of political and social transformation we examined how an expected rapid increase in body mass index (BMI) and waist circumference relates to changes in lipid(More)
BACKGROUND Vascular injury is the main mechanism in pathophysiology of PR3-ANCA-associated vasculitis. Soluble serum thrombomodulin (sTM) is a membrane-bound receptor for thrombin expressed by vascular endothelial cells. - OBJECTIVE The aim of study was to determine the blood levels of sTM in patients with PR3-ANCA-associated vasculitis. MATERIAL AND(More)
BACKGROUND Studies have shown a correlation between gender and an ability to change lifestyle to reduce the risk of disease. However, the results of these studies are ambiguous, especially where a healthy lifestyle is concerned. Additionally, health behaviors are strongly modified by culture and the environment. Psychological factors also substantially(More)
PURPOSE Despite major advances in cardiology dyslipidemia continues to be underdiagnosed and undertreated. The study aimed to evaluate current prevalence of dyslipidemia and treatment efficacy in both coronary and non-coronary subjects. METHODS 17,065 subjects aged 30-95 years (20.51%--coronary heart disease (CHD) patients), seeking medical help for(More)