Winston W. K. Koo

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Treatment with isolated allogeneic mesenchymal cells has the potential to enhance the therapeutic effects of conventional bone marrow transplantation in patients with genetic disorders affecting mesenchymal tissues, including bone, cartilage, and muscle. To demonstrate the feasibility of mesenchymal cell therapy and to gain insight into the transplant(More)
A piglet model was used to determine whether the fan beam dual energy X-ray absorptiometry technique (DXA) could be adapted for the measurement of body composition of small subjects. Commercial domestic swine piglets (n = 14) with weights between 1.95 and 21.1 kg had duplicate fan beam-DXA scans followed by chemical analysis of body composition. Each scan(More)
There is growing awareness of the need to understand the pattern and timing and other factors that affect the accrual of peak bone mass. This interest has emanated from concern about the increasing prevalence of osteoporotic fractures in older age groups, especially the elderly. It is logical to look for ways to maximize peak bone mass in order to minimize(More)
BACKGROUND Fan beam dual energy x-ray absorptiometry (FB DXA) has recently been validated for the measurement of body composition in small subjects. This study represents the first report of body composition (bone mineral content, fat mass, and lean mass) in human neonates measured by FB DXA. METHODS FB DXA measurements were performed in 73 healthy(More)
Critically ill newborns in neonatal intensive care units (NICUs) are at greater risk of developing adverse drug reactions (ADRs). Differentiation of ADRs from reactions associated with organ dysfunction/immaturity is difficult. Current ADR algorithm scoring was established arbitrarily without validation in infants. The study objective was to develop a valid(More)
Infants and children <5 yr were not included in the 2007 International Society for Clinical Densitometry Official Positions regarding Skeletal Health Assessment of Children and Adolescents. To advance clinical care of very young children, the International Society for Clinical Densitometry 2013 Position Development Conference reviewed the literature(More)
OBJECTIVE Palm and palm olein (PO) oils are used in some infant formula fat blends to match the fatty acid profile of human milk, but their presence has been shown to lower calcium and fat absorption. We aimed to determine if the reported differences in calcium absorption could affect skeletal development by comparing bone mineral accretion in healthy term(More)
OBJECTIVE To investigate the mode of transmission of and assess control measures for an outbreak of carbapenem-resistant (multidrug-resistant) Acinetobacter baumannii infection involving 6 premature infants. DESIGN An outbreak investigation based on medical record review was performed for each neonate during the outbreak (from November 2008 through(More)
Factors that affect quantitative ultrasound (QUS) bone measurements have not been clearly defined for all clinical populations. To determine some technical and clinical aspects that may affect QUS bone measurement in the neonate–maternal dyad. Speed of sound (SOS) was measured at the radius and tibia using a commercial multisite axial transmission QUS(More)
OBJECTIVE To evaluate the published clinical data on the physiologic effects of using palm oil and its low melting fraction, palm olein (PO) as a dominant lipid source in the fat blend in infant formulas. DESIGN A systematic search of Medline and the Cochrane Database of Systematic Reviews was performed to retrieve studies comparing infants who received(More)