Winston Crasto

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BACKGROUND Obesity is a risk factor for both chronic kidney disease (CKD) and cardiovascular disease. The association of simple indices of obesity with CKD remains poorly understood. Evidence suggests that measures of central obesity such as waist circumference (WC) and waist-to-hip ratio (WHR) are more accurate predictors of morbidity and cardiovascular(More)
Effective glycaemic control can reduce and potentially prevent the microvascular and macrovascular complications of diabetes. Insulin is the mainstay of treatment for type 1 diabetes and is indicated in patients with type 2 diabetes who do no achieve optimal glycaemic control despite the use of oral hypoglycaemic agents. The advent of the so-called(More)
Exenatide, a synthetic glucagon GLP-1 receptor agonist, belongs to a new class of agents approved as a treatment option in patients with poorly controlled type 2 diabetes not adequately controlled on oral antidiabetic agents. The principal mode of drug action includes enhanced glucose-dependent insulin secretion --the so called "incretin effect"--(More)
Some patients with type 2 diabetes mellitus (T2DM) are profoundly insulin resistant and require large insulin doses to achieve optimal glycaemic control. However, large volumes of subcutaneous conventional U-100 insulin can cause discomfort at the injection site, resulting in poor concordance with insulin therapy. One therapeutic option is the use of U-500(More)
AIMS To determine whether tighter cardiovascular risk factor control with structured education in individuals with type 2 diabetes (T2DM) and microalbuminuria benefits cardiovascular risk factors. METHODS Participants from a multiethnic population, recruited from primary care and specialist clinics were randomised to intensive intervention with structured(More)
Dear editor, Much has been written about maintaining the safety of patients on glucocorticoid replacement during illness sometimes inadequate response of nonendocrine colleagues providing inpatient care. Another group of patients that merit urgent attention in the inpatient setting are those with diabetes insipidus. In the UK, there has been one case(More)
Data suggest increased rates of chronic kidney disease (CKD) in those with undiagnosed hypertension (HTN). Our study aimed to determine the prevalence of CKD in undiagnosed hypertensives in a previously unreported subgroup of individuals of South Asian ethnicity. We analysed data from subjects in the ADDITION-Leicester study, a UK based multiethnic,(More)
Reproductive health is an important domain of women’s health care and broadly encompasses conditions which impact fertility, conception or birth of a healthy infant. Although numerous factors or conditions are associated with infertility, polycystic ovary disease is a well recognised cause. In this regard, metformin which belongs to the biguanide group of(More)
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