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It is now clear that members of the ICE/CED-3 protease Philadelphia, Pennsylvania 19107–5541 family play key biological roles in inflammation and e_alnemri@lac.jci.tju.edu mammalian apoptosis. To date, ten homologs of human 2 Vertex Pharmaceuticals, Inc. origin have been published (Figure 1). The frenetic pace Cambridge, Massachusetts 02139 of(More)
IL-lp-converting enzyme (ICE) cleaves pro-IL-lp to generate mature IL-lp. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1I~ after stimulation with lipopolysaccharide.(More)
Recent studies have shown that protein kinase C (PKC) delta is proteolytically activated at the onset of apoptosis induced by DNA-damaging agents, tumor necrosis factor, and anti-Fas antibody. However, the relationship of PKC delta cleavage to induction of apoptosis is unknown. The present studies demonstrate that full-length PKC delta is cleaved at(More)
Previous work using the in vitro bovine lens as a model has shown a correlation between toxicity and lens optical function and showed much higher sensitivity in detecting irritancy of several surfactants at much lower concentrations than the Draize score. In the current study, cultured bovine lenses were used to study the effects of the surfactant sodium(More)
Health care professionals are increasingly aware that persons are complex and live in relation with other complex human communities and broader systems. Complex beings and systems are living and evolving in nonlinear ways through a process of mutual influence. Traditional standardized approaches in chronic disease management do not address these non-linear(More)
Ultrasound biomicroscopy produces real-time two-dimensional images of ocular structures measured non-invasively. Given recent work which shows that lenses from myopic eyes show shorter focal lengths and reduced accommodative amplitudes compared with controls, this study was undertaken to determine the structural characteristics of the anterior segment of(More)
The human receptor for the complement cleavage fragments C3b and C4b (complement receptor type 1, CRl) is found on the surfaces of erythrocytes, most peripheral blood leukocytes, glomerular podocytes, and follicular dendritic cells, and in plasma (1-3). Besides the removal of C3b-or C4b-coated microorganisms or immune complexes (4), CRl also serves as an(More)
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