Winnie Wing-Yin Wong

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It is now clear that members of the ICE/CED-3 protease Philadelphia, Pennsylvania 19107–5541 family play key biological roles in inflammation and mammalian apoptosis. To date, ten homologs of human 2 Vertex Pharmaceuticals, Inc. origin have been published (Figure 1). The frenetic pace Cambridge, Massachusetts 02139 of(More)
IL-lp-converting enzyme (ICE) cleaves pro-IL-lp to generate mature IL-lp. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1I~ after stimulation with lipopolysaccharide.(More)
Recent studies have shown that protein kinase C (PKC) ␦ is proteolytically activated at the onset of apoptosis induced by DNA-damaging agents, tumor necrosis factor, and anti-Fas anti-body. However, the relationship of PKC ␦ cleavage to induction of apoptosis is unknown. The present studies demonstrate that full-length PKC ␦ is cleaved at DMQD 330 N to a(More)
Covalently closed circular DNA (cccDNA) is a crucial intermediate in the replication of hepadnaviruses. We inhibited the replication of duck hepatitis B virus in congenitally infected ducks with a combination of lamivudine and a dideoxyguanosine prodrug. Inhibition of viral replication should prevent renewal of the cccDNA pool, and its decay was measured in(More)
Previous work using the in vitro bovine lens as a model has shown a correlation between toxicity and lens optical function and showed much higher sensitivity in detecting irritancy of several surfactants at much lower concentrations than the Draize score. In the current study, cultured bovine lenses were used to study the effects of the surfactant sodium(More)
BACKGROUND Multiple sclerosis (MS) has a low prevalence in Hong Kong. OBJECTIVE To reassess MS prevalence in Hong Kong and to examine associated risk factors for relapsing-remitting type MS patients to reach Kurtzke's Extended Disability Status Scale (EDSS) of 6.0, i.e. when walking aid was needed. DESIGN Retrospective observational study on MS patients(More)
The human receptor for complement fragments C3b and C4b (complement receptor type I, CR1) is found on erythrocytes, peripheral blood leukocytes, glomerular podocytes, and follicular dendritic cells and has an important role in the processing and clearance of C3b/C4b-coated microorganisms and immune complexes (1, 2). CR 1 also acts as a cofactor for the(More)
Ultrasound biomicroscopy produces real-time two-dimensional images of ocular structures measured non-invasively. Given recent work which shows that lenses from myopic eyes show shorter focal lengths and reduced accommodative amplitudes compared with controls, this study was undertaken to determine the structural characteristics of the anterior segment of(More)
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