Winfried Lachnit

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Extracellular ATP is implicated in numerous sensory processes ranging from the response to pain to the regulation of motility in visceral organs. The ATP receptor P2X3 is selectively expressed on small diameter sensory neurons, supporting this hypothesis. Here we show that mice deficient in P2X3 lose the rapidly desensitizing ATP-induced currents in dorsal(More)
The HERMES experiment is collecting data on inclusive and semi-inclusive deep inelastic scattering of polarised positrons from polarised targets of H, D, and He. These data give information on the spin structure of the nucleon. This paper describes the forward angle spectrometer built for this purpose. The spectrometer includes numerous tracking chambers(More)
1. The alpha 1-adrenoceptor population mediating contraction of caudal artery of rat has been characterized by using quantitative receptor pharmacology. 2. Cumulative concentration-effect (E/[A]) curves to noradrenaline (NA) yielded a p[A]50 of 5.56 +/- 0.05 (n = 16). Prazosin caused concentration-dependent, parallel, dextral shifts of E/[A] curves to NA(More)
Several isomers of hexachlorocyclohexanes (HCHs) have been shown to be toxic to mammals. Previous studies have revealed that the delta isomer (delta-HCH) was particularly potent toward disrupting Ca2+ homeostasis in a variety of excitable and nonexcitable cells and altering contractility of cardiac muscle. The effects of the delta and gamma isomers of HCH(More)
We have determined the densities of sarcolemmal voltage-dependent Ca2+ channels (VDCC) and Ca(2+)-induced Ca2+ release channels (CICR) of sarcoplasmic reticulum (SR) in the cardiomyopathic hamster heart using [3H]PN-200 and [3H]ryanodine, respectively. Partially purified cardiac membrane preparations from myopathic animals exhibit a twofold higher capacity(More)
In this report, the regulatable expression by tetracycline of the rat recombinant P2X(3) receptor in stably transfected Chinese hamster ovary (CHO-K1) expressing the tetracycline-controlled transactivator (tTA) is described. cDNA encoding the rat P2X(3)-receptor was subcloned into pTRE (a tetracycline-repressible expression vector) which was used to(More)
A. Airapetian,32 N. Akopov,32 M. Amarian,24,27,32 E. C. Aschenauer,13,14,6 H. Avakian,10 R. Avakian,32 A. Avetissian,32 E. Avetissian,10,32 B. Bains,15 C. Baumgarten,22 M. Beckmann,12 S. Belostotski,25 J. E. Belz,28,29 Th. Benisch,8 S. Bernreuther,8 N. Bianchi,10 J. Blouw,24 H. Böttcher,6 A. Borissov,6,14 M. Bouwhuis,15 J. Brack,4 S. Brauksiepe,12 B.(More)
  • C. Adloff, V. Andreev, +162 authors S. Levonian
  • 2007
Cross sections for elastic photoproduction of J= and mesons are presented. For J= mesons the dependence on the photon-proton centre-of-mass energy W p is analysed in an extended range with respect to previous measurements of 26 W p 285 GeV. The measured energy dependence is parameterized as p/ W Æ p with Æ = 0:83 0:07. The differential cross section d =dt(More)
Deep-inelastic ep scattering data, taken with the H1 detector at HERA, are used to study the event shape variables thrust, jet broadening, jet mass, C parameter and two kinds of differential two-jet rate. The data cover a large range of the four-momentum transfer Q, which is considered to be the relevant energy scale, between 7GeV and 100GeV. The Q(More)