Wim Vandenberghe

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High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear. Exaggerated oscillatory synchronization in the beta (13-30 Hz) frequency band has been associated with bradykinesia in patients with PD. Accordingly, we tested the(More)
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring. However, the relative contributions of these proteins to the composition of(More)
The transmembrane protein stargazin enhances levels of functional AMPA receptors at the neuronal plasma membrane and at synapses. To clarify the mechanism for this effect, we studied trafficking of the AMPA receptor subunit glutamate receptor 1 (GluR1) in transfected COS7 cells. GluR1 expressed poorly on the surface of these cells and was primarily retained(More)
Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy). However, the molecular mechanisms underlying Parkin-mediated mitophagy are poorly understood. Here, we investigated whether(More)
Andrea A. Kühn,1,3 Florian Kempf,3 Christof Brücke,3 Louise Gaynor Doyle,1 Irene Martinez-Torres,1,2 Alek Pogosyan,1 Thomas Trottenberg,3 Andreas Kupsch,3 Gerd-Helge Schneider,4 Marwan I. Hariz,1,2 Wim Vandenberghe,5 Bart Nuttin,6 and Peter Brown1 1Sobell Department of Motor Neuroscience and Movement Disorders and 2Unit of Functional Neurosurgery, Institute(More)
In this paper, the W-iLab.t wireless testbed is presented. The testbed consists of nearly 200 sensor nodes and an equal amount of WiFi nodes, which are installed across three floors of an office building. The testbed supports wireless sensor experiments, WiFi based mesh and ad hoc experiments, and mixed sensor/WiFi experiments. It is explained how changes(More)
This document discusses the status of research on detection and prevention of financial fraud undertaken as part of the IST European Commission funded FF POIROT (Financial Fraud Prevention Oriented Information Resources Using Ontology Technology) project. A first task has been the specification of the user requirements that define the functionality of the(More)
Internet systems are currently too complex to be entirely designed in advance and therefore must be thoroughly evaluated in realistic environments. Experimentally driven research is at the heart of Future Internet Research and Experiment (FIRE) facilities, which target various experimenter profiles, ranging from core Internet communities and sensor networks(More)
Wireless Building Automation is a complex problem dealing with a lot of trade offs: on one hand sensors and actuators have to be as energy-efficient as possible, while on the other hand the overall network should be performant and resilient enough to extend or even replace a wired backbone. In addition, the network should be able to serve existing IEEE(More)