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Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant, and Nec-1 stable (Nec-1s), its more stable variant. We report that Nec-1 is(More)
The mechanism of the glycoside hydrolase family 90 Salmonella phage P22 tailspike protein was reevaluated by automated docking using Autodock3, with O–antigen oligosaccharide fragments having different ring– conformations at L–rhamnose and that span the essential –1 to +1 subsites. In contrast to a previously suggested mechanism, the docking results(More)
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