Wim J . G . Oyen

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In recent years, a number of new developments in targeted therapies using radiolabeled compounds have emerged. New developments and insights in radioiodine treatment of thyroid cancer, treatment of lymphoma and solid tumors with radiolabeled monoclonal antibodies (mAbs), the developments in the application of radiolabeled small receptor-specific molecules(More)
BACKGROUND In this study, pretargeted immuno-positron-emission tomography [PET] with a bispecific monoclonal anti-carcinoembryonic antigen [CEA] (CEACAM5) × anti-hapten antibody (bispecific monoclonal antibody [bsmAb]) and a small (1.5 kD) peptide labeled with 68Ga was compared to fludeoxyglucose [18F-FDG]-PET for detecting intraperitoneal [i.p.](More)
Positron emission tomography (PET) using [(18)F]-2-deoxy-2-fluoro-d-glucose (FDG) has emerged as a valuable diagnostic modality in patients with non-small cell lung cancer (NSCLC). Data in the literature show that the addition of FDG-PET definitely alters clinical management in patients with potentially resectable NSCLC by adequately staging the mediastinum(More)
Targeted treatment has substantially changed the field of oncology. Compared with cytotoxic chemotherapy, many novel targeted therapies are administered over long periods of time, and result in disease stabilization rather than tumor shrinkage. The activity of these novel agents might, therefore, be better reflected by changes in molecular features of the(More)
The role of fluorodeoxyglucose positron emission tomography (FDG PET) in the diagnostic localization of infectious diseases has expanded rapidly in recent years. In general, sensitivity of FDG PET in depicting infections compares favorably to other diagnostic modalities. It is shown to be useful in patients with suspected osteomyelitis, especially in(More)
residual tumor and metastases with 131J is a potentially curative therapeutic approach for differentiated, nonmedul lary thyroid carcinoma (approximately 75%—85% of all thyroid carcinomas). However, several diagnostic strategies can be applied for planning 1311treatment. In routine clinical practice, low-dose 1311imaging under hypothyroid condi tions;(More)
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