Wilson Toussile

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A long standing issue in population genetics is the identification of genetically homogeneous populations. The most widely used measures of population structure are Wright's F statistics (Wright 1931). But the fundamental prerequisite of any inference based on these statistics is the definition of populations and this definition is typically subjective(More)
Malaria control strategies aiming at reducing disease transmission intensity may impact both oocyst intensity and infection prevalence in the mosquito vector. Thus far, mathematical models failed to identify a clear relationship between Plasmodium gametocytes and their infectiousness to mosquitoes. Natural isolates of gametocytes are genetically diverse and(More)
Plasmodium falciparum infections in malaria endemic areas often harbor multiple clones of parasites. However, the transmission success of the different genotypes within the mosquito vector has remained elusive so far. The genetic diversity of malaria parasites was measured by using microsatellite markers in gametocyte isolates from 125 asymptomatic(More)
Dissecting the genomic spectrum of clinical disease entities is a challenging task. Recursive partitioning (or classification trees) methods provide powerful tools for exploring complex interplay among genomic factors, with respect to a main factor, that can reveal hidden genomic patterns. To take confounding variables into account, the partially linear(More)
Malaria control strategies aiming at reducing disease transmission intensity may impact both oocyst intensity and infection prevalence in the mosquito vector. Thus far, mathematical models failed to identify a clear relationship between Plasmodium gametocytes and their infectiousness to mosquitoes. Natural isolates of gametocytes are genetically diverse and(More)
A long standing issue in population genetics is the identification of genetically homogeneous populations. The most widely used measures of population structure are Wright's F statistics (Wright 1931). But the fundamental prerequisite of any inference based on these statistics is the definition of populations and this definition is typically subjective(More)
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