William Y. Moores

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A simple expression is derived to describe the partial pressure at 50% hemoglobin saturation with oxygen (P50) that maximizes venous oxygen tension (PO2) for a given arterial PO2 and oxygen consumption. That "optimal P50" also maximizes arteriovenous saturation differences for given arterial and venous PO2 values. The optimal P50 can be expressed as the(More)
16. Rosenfeld CR: Distribution of cardiac output in ovine pregnancy. Am J Physiol: Heart Circ Physiol 1: H231-H235, 1977 20 17. Webster AJF, White F: Portal blood flow and heat production in the digeitive tract of jheep. BrJNutr 29: 279-292, 1973 21. 18. Greenway CV, Stark RD: Hepatic vascular bed. Physiol Rev 51: 2365,1971 22 19. Chacko AW, Reynolds SRM:(More)
We determined the mechanical and metabolic effects of graded myocardial ischemia in 23 open-chest, anesthetized pigs. By connecting the midportion of the left anterior descending artery (LAD) to the carotid artery via a constant volume, calibrated pump, we reduced the flow in the LAD to 0, 25, 50, and 75% of control rates for periods of 1 h. Flows of 100%(More)
Increasing numbers of operations requiring cardiopulmonary bypass have been accompanied by greater demands for blood resources. Improved techniques of blood conservation have diminished the average blood requirements per operation and have increased the percent of operations that can be done without homologous blood. The conservation of blood can be planned(More)
Because of anatomic differences between the right and left heart, we hypothesized that the reduction in left ventricular stroke volume during acute cardiac tamponade is the passive result of decreased pulmonary venous return due primarily to right heart compression. To test this hypothesis, two types of experiments were performed in dogs. Group 1: in fresh,(More)
Oxygen transport and delivery to peripheral tissues during hypothermia are analyzed theoretically, taking into consideration various conditions observed both in nature and clinically. With decreasing temperature, P50 (the oxygen tension [Po 2] at 50% hemoglobin saturation with oxygen) decreases, thereby leading to low mixed venous oxygen tension ( $$P\bar(More)