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OBJECTIVE Despite extensive evidence for genetic susceptibility to diabetic nephropathy, the identification of susceptibility genes and their variants has had limited success. To search for genes that contribute to diabetic nephropathy, a genome-wide association scan was implemented on the Genetics of Kidneys in Diabetes collection. RESEARCH DESIGN AND(More)
The androgen testosterone is essential for the Sertoli cell to support the maturation of male germ cells and the production of spermatozoa (spermatogenesis). In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces a conformational change in AR such that the receptor-steroid complex has high affinity(More)
Sphinx-4 is an open source HMM-based speech recognition system written in the Java™ programming language. The design of the Sphinx-4 decoder incorporates several new features in response to current demands on HMM-based large vocabulary systems. Some new design aspects include graph construction for multilevel parallel decoding with multiple feature streams(More)
OBJECTIVE Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes. RESEARCH DESIGN AND METHODS To efficiently search for genomic regions harboring diabetic nephropathy genes, we(More)
Chromosomal integration enables human immunodeficiency virus (HIV) to establish a permanent reservoir that can be therapeutically suppressed but not eradicated. Participation of cellular proteins in this obligate replication step is poorly understood. We used intensified RNA interference and dominant-negative protein approaches to show that the cellular(More)
The Meeting Central prototype is a suite of collaboration tools designed to support distributed meetings. The tools' minimalist design provides only those features that have the most impact on distributed meeting effectiveness. The collaboration suite is built on top of a distributed, extensible, and scalable framework.
In congenital and acquired long QT type 2, women are more vulnerable than men to torsade de pointes. In prepubertal rabbits (and children), the arrhythmia phenotype is reversed; however, females still have longer action potential durations than males. Thus, sex differences in K(+) channels and action potential durations alone cannot account for(More)
To participate in musical improvisations, an interacting system must both generate appropriate musical materials and express those materials appropriately in collaboration with other performers. We have used results from the study of conversation and discourse to identify the major components for a theory of improvisation—listening, composing, and(More)
FSH binding to Sertoli cells is required for optimal production of sperm in mammals. The cAMP response element-binding protein (CREB) is a major mediator of FSH-induced changes in gene expression. To determine whether CREB is required for spermatogenesis, an adenovirus encoding a phosphorylation-defective CREB mutant (AdCREBm1) was used to inhibit CREB(More)