Mitochondrial metabolism provides precursors to build macromolecules in growing cancer cells. In normally functioning tumour cell mitochondria, oxidative metabolism of glucose- and glutamine-derived carbon produces citrate and acetyl-coenzyme A for lipid synthesis, which is required for tumorigenesis. Yet some tumours harbour mutations in the citric acid… (More)
Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration. Metformin… (More)
Mitochondrial metabolism provides precursors to build macromolecules in growing cancer cells 1,2. In normally-functioning tumor cell mitochondria, oxidative metabolism of glucose-and glutamine-derived carbon produces citrate and acetyl-CoA for lipid synthesis, which is required for tumorigenesis 3. Yet some tumors harbor mutations in the citric acid cycle… (More)
Treatment of patients with the hypereosinophilic syndrome with mepolizumab. A genome‐wide association study identifies K1AA0350 as a type 1 diabetes gene. Nature, 448(7153), 591‐594.