William W Storms

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BACKGROUND Exercise-induced bronchoconstriction (EIB) describes acute airway narrowing that occurs as a result of exercise. EIB occurs in a substantial proportion of patients with asthma, but may also occur in individuals without known asthma. METHODS To provide clinicians with practical guidance, a multidisciplinary panel of stakeholders was convened to(More)
It has long been recognized, even during biblical times, that physical exercise may induce asthma symptoms in susceptible individuals. Nevertheless, the term exerciseinduced asthma (EIA) only became popular in the 1960s and 1970s when several reports addressed the pattern of airway response to exercise and the influence of drugs on EIA, particularly in(More)
Chief Editors: John M. Weiler, MD, MBA, President, CompleWare Corporation, Professor Emeritus, University of Iowa, Iowa City, Iowa; Sandra D. Anderson, PhD, DSc, Clinical Professor, Sydney Medical School, Royal Prince Alfred Hospital, Department of Respiratory and Sleep Medicine, Camperdown NSW 2050, Australia; Christopher Randolph, MD, Clinical Professor(More)
OBJECTIVE Intranasal beclomethasone dipropionate (BDP) has generally been considered to have no systemic activity at recommended doses, but the potential for long-term effects on growth has not previously been evaluated. This study was undertaken to assess the effects of 1 year of treatment with intranasal BDP on growth in children. STUDY DESIGN In this(More)
PURPOSE The purpose of this manuscript is to review the recent literature on exercise-induced asthma (EIA) and summarize the pathogenesis, diagnosis, and treatment of this condition. METHOD A review of the English language medical literature was performed to obtain articles on EIA. RESULTS The pathophysiology of EIA is not fully understood, but there(More)
People with allergic rhinitis rate their overall health significantly lower than individuals without nasal allergies. Compared with the general population, more people with AR complain of difficulty getting to sleep, waking up during the night, lack of a good night's sleep, or a combination of these, as a result of their nasal symptoms. More than half of(More)
Many clinicians base their treatment choices on trial outcomes. To determine if clinical trial results apply to the general patient population, several factors need to be considered. The exclusion and inclusion of patients in a trial may present selection bias. Adherence to therapy in trials often varies widely compared with adherence seen in clinical(More)
BACKGROUND Azelastine nasal spray and oral cetirizine are selective histamine H(1)-receptor antagonists that are approved in the United States for the treatment of seasonal allergic rhinitis (SAR). OBJECTIVE The objective of the present study was to compare the efficacy and tolerability of azelastine nasal spray administered at the recommended dosage of 2(More)
OBJECTIVE To evaluate how well the medications currently approved in the United States for allergic rhinitis (AR) treat nasal symptoms when examined according to Food and Drug Administration-indicated uses and dosages. DATA SOURCES MEDLINE (1966 onward), EMBASE (1974 onward), and the Cochrane Library (2007) were systematically searched according to the(More)