William Valentine-Cooper

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This paper describes the software package KELVIN, which supports the PPL (posterior probability of linkage) framework for the measurement of statistical evidence in human (or more generally, diploid) genetic studies. In terms of scope, KELVIN supports two-point (trait-marker or marker-marker) and multipoint linkage analysis, based on either sex-averaged or(More)
Two wide-spread and powerful techniques in human genetic epidemiology are linkage and association analysis. Linkage analysis is used to identify the approximate location of disease-related genes on a map of the human genome, and generally uses pedigree data and large sets of genetic markers. Since the resolution of locality approximations determined using(More)
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