William T Toner

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The phenomenon of "acute tolerance" to thiopentone was re-examined in 82 subjects with induction doses of 2-15mg kg-1. There was a strong positive correlation between the venous plasma thiopentone concentrations on recovery from anesthesia and the induction dose, expressed as either mg kg-1 or mg m-2. Recovery time was proportionately shorter with larger(More)
Midazolam, a new water-soluble benzodiazepine, was given intravenously in 5 and 10 mg doses to nine volunteers and plasma levels estimated at intervals for 24 hours. Recovery was also studied. the drug was easy and painless to inject and venous thrombosis was not found in this series. While there was a great individual variation in response to the drug this(More)
The H2-receptor antagonist, cimetidine, was used instead of magnesium trisilicate BPC as routine antacid therapy before both elective and emergency obstetric anesthesia. Two trials of its efficacy in increasing intragastric pH and decreasing the volume of gastric contents in parturients are reported. In the first trial, 400 mg of cimetidine given orally to(More)
A standard dose of lorazepam 2.5 mg was given i.v. to two groups of mothers: (a) before surgical induction of labour and (b) at the beginning of the second stage of labour. A group of non-pregnant women was studied as control. Plasma concentrations of lorazepam were measured by gas-liquid chromatography, in the mothers before delivery, and in the mother and(More)
As a test of muon-electron universality we have compared muon-proton and electron-proton inelastic scattering cross sections for lq21 (square of the four-momentum transferred from the lepton) values up to 4.0 (GeV/c)2 and for lepton energy losses up to 9 GeV. There is no experimentally significant deviation from muon-electron universality . If the muon is(More)
We report on the inclusive electroproduction of hadrons from nucleon targets. The incident electron beam energy is 19.5 GeV. We detect scattered electrons corresponding to exchanged virtual photons in the range -0.25 > q2 > -3.00 (GeV/c)2 and 12 < s < 30 GeV2. In coincidence we detect most hadrons which go in the forward (virtual photon) direction in the(More)