William Spinelli

Learn More
Data pre-filtering is often used in linear identification to increase model accuracy in a specified frequency band, as pre-filtering is equivalent to a frequency weighting on the prediction error function. However, this interpretation applies only to a strictly linear setting of the identification problem. In this paper, the role of data and error(More)
We have characterized in vitro the muscarinic receptors mediating the contraction of the detrusor muscle in Cynomolgus monkeys and guinea pigs using carbachol as the agonist and 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP, M3-selective), methoctramine (M2-selective) and pirenzepine (M1-selective) as the antagonists. Carbachol induced a(More)
The authors have previously shown that the use-dependent action of lidocaine on the Vmax of canine Purkinje fibers and on intraventricular conduction in the in situ heart undergoes significant developmental changes. In this study, they use standard microelectrode techniques to test whether these age-related differences are due to the charged, more(More)
  • 1