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Human GLTP: Three distinct functions for the three tryptophans in a novel peripheral amphitropic fold.
Human glycolipid transfer protein (GLTP) serves as the GLTP-fold prototype, a novel, to our knowledge, peripheral amphitropic fold and structurally unique lipid binding motif that defines the GLTPExpand
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Photophysics of ANS. I. Protein-ANS complexes: Intestinal fatty acid binding protein and single-trp mutants.
We continue investigations into the physical chemistry of intestinal fatty acid binding protein, I-FABP, and its interaction with ANS and other ligands [cf references [Kirk, W., E. Kurian, and F.Expand
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Environment and Mobility of a Series of Fluorescent Reporters at the Amino Terminus of Structurally Related Peptide Agonists and Antagonists Bound to the Cholecystokinin Receptor*
Fluorescence is a powerful biophysical tool for the analysis of the structure and dynamics of proteins. Here, we have developed two series of new fluorescent probes of the cholecystokinin (CCK)Expand
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Measurement of intermolecular distances for the natural agonist Peptide docked at the cholecystokinin receptor expressed in situ using fluorescence resonance energy transfer.
Fluorescence resonance energy transfer is a powerful biophysical technique used to analyze the structure of membrane proteins. Here, we used this tool to determine the distances between a distinctExpand
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Enhanced biological cathodoluminescence
We have combined the specificity of antibody labeling, the power of fluorescence detection, and the resolution of scanning electron microscopy (SEM) to identify antigenic sites on nanometer-scaleExpand
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Photophysics of ANS. V. Decay modes of ANS in proteins: the IFABP-ANS complex.
The fluorescence properties of ANS as bound to proteins are treated. Several points of view concerning the origin of these properties are reviewed and synthesized into one framework. On proteinsExpand
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Lanthanide-dependent perturbations of luminescence in indolylethylenediaminetetraacetic acid-lanthanide chelate
Using a synthetic EDTA analog built out of tryptophan, we have investigated the photophysics of the interaction of indole with various lanthanides chelated in close enough proximity to the indole toExpand
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Photophysics of ANS. IV. Electron transfer quenching of ANS in alcoholic solvents and mixtures.
ANS is observed to decay from the fluorescent state with distributed kinetics in nearly pure ethanol solvent, notwithstanding that in mixed ethanol/water solvents the decay is discrete andExpand
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Immuno-Fluorescence Scanning Electron Microscopy of Biological Cells
Scanning electron microscopy (SEM) can produce striking three-dimensional images of biological cells and tissues with submicron resolution of surface morphology. Such cell surfaces are often complexExpand
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Transverse ionic mobility measured in a dynamic light scattering device.
We describe here some novel experiments with a commercial dynamic light scattering device. By inserting a quarter-wave plate in the light beam of the HeNe laser used in the Malvern DLS 'Zetasizer',Expand
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