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Incomplete retinal vascularization occurs in both Norrie disease and familial exudative vitreoretinopathy (FEVR). Norrin, the protein product of the Norrie disease gene, is a secreted protein of unknown biochemical function. One form of FEVR is caused by defects in Frizzled-4 (Fz4), a presumptive Wnt receptor. We show here that Norrin and Fz4 function as a(More)
CONTEXT Age-related macular degeneration is a prevalent disease of aging that may cause irreversible vision loss, disability, and depression. The latter is rarely recognized or treated in ophthalmologic settings. OBJECTIVE To determine whether problem-solving treatment can prevent depressive disorders in patients with recent vision loss. DESIGN(More)
PURPOSE To compare the efficacy of behavior activation (BA) + low vision rehabilitation (LVR) with supportive therapy (ST) + LVR to prevent depressive disorders in patients with age-related macular degeneration (AMD). DESIGN Single-masked, attention-controlled, randomized, clinical trial with outcome assessment at 4 months. PARTICIPANTS Patients with(More)
Age-Related Macular Degeneration (AMD) is the leading cause of severe vision loss in older adults and impairs the ability to read, drive, and live independently and increases the risk for depression, falls, and earlier mortality. Although new medical treatments have improved AMD's prognosis, vision-related disability remains a major public health problem.(More)
BACKGROUND/METHODS The objective of this study was to determine whether relinquishing cognitive, physical, and social activities is associated with an increased risk of cognitive decline in patients with age-related macular degeneration (AMD). We conducted a 3-year longitudinal study of 206 nondemented patients with AMD. RESULTS Twenty-three subjects(More)
OBJECTIVE To determine whether dissatisfaction with performance of valued activities predicts depression in patients with age-related macular degeneration (AMD). PATIENTS Two hundred and six patients with newly diagnosed neovascular AMD in one eye and pre-existing AMD in the fellow eye who were participating in a clinical trial of a psychosocial(More)
The Third International Symposium on Retinopathy of Prematurity (ROP) was convened with the aim of cross fertilizing the horizons of basic and clinical scientists with an interest in the pathogenesis and management of infants with ROP. Ten speakers in the clinical sciences and ten speakers in the basic sciences were recruited on the basis of their research(More)
Two brothers, one with bilateral inferotemporal retinal dialyses and the other with a unilateral inferotemporal dialysis, are described. From a review of the literature and these two cases it is concluded that when a patient with bilateral non-traumatic retinal dialyses is discovered other family members should be examined.
Two visually monocular patients with retinopathy of prematurity, followed up for 14 and 5 years, developed progressive visual loss in their twenties and thirties, respectively. In one patient, who underwent no surgery, visual acuity deteriorated from 20/30 to 20/400 over a 14-year period. The second patient had surgery for retinal detachment. Visual acuity(More)
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