William S. Tasman

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Incomplete retinal vascularization occurs in both Norrie disease and familial exudative vitreoretinopathy (FEVR). Norrin, the protein product of the Norrie disease gene, is a secreted protein of unknown biochemical function. One form of FEVR is caused by defects in Frizzled-4 (Fz4), a presumptive Wnt receptor. We show here that Norrin and Fz4 function as a(More)
OBJECTIVES To report the prevalence rate of depression in older patients with recent vision loss due to age-related macular degeneration (AMD) and to describe the effect of depression on self-reported vision function during 6 months. METHODS Prospective cohort study of 51 older patients with recent-onset bilateral AMD attending the Retina Clinic of Wills(More)
PURPOSE Retained lens fragments after cataract surgery is an infrequent, but potentially serious surgical complication. The aim of this study is to evaluate outcomes after vitrectomy has been performed for removal of retained lens material. METHODS A retrospective review was conducted to evaluate all cases of pars plana vitrectomy for removal of retained(More)
The authors report a series of 20 eyes from 20 patients in whom inadvertent perforation of the globe occurred during local anesthesia for ocular surgery. Perforation resulted from retrobulbar anesthesia in 18 eyes and from peribulbar anesthesia in 2 eyes. Nine (45%) of 20 eyes had an axial length greater than or equal to 26.00 mm. Combining this figure with(More)
Linkage analysis with restriction fragment length polymorphisms for the gene for type II procollagen (COL2A1) was carried out in a family with the Stickler syndrome, or arthro-ophthalmopathy, an autosomal dominant disorder that affects the eyes, ears, joints, and skeleton. The analysis demonstrated linkage of the disease and COL2A1 with a logarithm-of-odds(More)
One form of retinopathy associated with diabetes is a proliferative small vessel process thought to be mediated by biochemical, hemodynamic, and endocrinologic factors. The authors conducted a prospective study to determine whether patients with diabetes who had proliferative retinopathy had evidence of intracranial microangiopathy visible at magnetic(More)
OBJECTIVE To compare the refractive outcome of eyes treated with cryotherapy for threshold retinopathy of prematurity (ROP) with eyes treated with laser photocoagulation. DESIGN Extended follow-up of a randomized controlled clinical trial. PARTICIPANTS One hundred eighteen eyes from 66 patients were randomly assigned to receive either cryotherapy or(More)
OBJECTIVE To assess visual and structural outcomes after laser photocoagulation and transscleral cryotherapy for threshold retinopathy of prematurity (ROP) after 10 years. DESIGN Extended follow-up of a randomized controlled clinical trial. PARTICIPANTS One hundred eighteen eyes from 66 patients were randomly assigned to receive either cryotherapy or(More)