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Particulate air pollution has been associated with respiratory and cardiovascular disease. Evidence for cardiovascular and neurodegenerative effects of ambient particles was reviewed as part of a workshop. The purpose of this critical update is to summarize the evidence presented for the mechanisms involved in the translocation of particles from the lung to(More)
Proteins containing a limited number of N-terminal motifs followed by nucleotide-binding domain and leucine-rich repeat regions are emerging as important regulators for immunity. A search of human genome scaffold databases has identified a large family of known and unknown genes, which we have recently called the CATERPILLER (caspase recruitment domain,(More)
—We are architecting and deploying a multi-hop wireless network in one of Houston's most economically disadvantaged neighborhoods. The objective of this network is to empower under-resourced communities with access to technology and educational and work-at-home tools. Here, we present the societal objectives of the network, describe the joint technical and(More)
Although activated human T cells express MHC class II antigens, the regulation of these antigens in T cells is poorly understood. This study focuses on the control of the MHC2TA gene in these cells. MHC2TA encodes the transcriptional master regulator of MHC class II, the class II trans-activator (CIITA). It has at least three distinct promoters (PI, PIII,(More)
BACKGROUND Controlled exposures of animals and humans to particulate matter (PM) or ozone air pollution cause an increase in plasma levels of endothelin-1, a potent vasoconstrictor that regulates pulmonary arterial pressure. OBJECTIVES The primary objective of this field study was to determine whether Mexico City children, who are chronically exposed to(More)
Recent studies have advanced our knowledge about the signal transduction cascade involved in the activation of nuclear factor (NF) ␬ B, including the identification and characterization of I ␬ B kinases (IKKs). Although exposure to hydrogen perox-ide (H 2 O 2) in vitro can activate NF-␬ B, this response is not universal and depends on the cell type and(More)
BACKGROUND RNA interference (RNAi) technology is a powerful methodology recently developed for the specific knockdown of targeted genes. RNAi is most commonly achieved either transiently by transfection of small interfering (si) RNA oligonucleotides, or stably using short hairpin (sh) RNA expressed from a DNA vector or virus. Much controversy has surrounded(More)
We analyzed the chest radiographs (CXRs) of 249 clinically healthy children, 230 from southwest Mexico City and 19 from Tlaxcala. In contrast to children from Tlaxcala, children from southwest Mexico City were chronically exposed to ozone levels exceeding the U.S. National Ambient Air Quality Standards for an average of 4.7 hr/day and to concentrations of(More)
BACKGROUND Exposure to ambient air particulate matter (PM) has been shown to increase rates of cardiopulmonary morbidity and mortality, but the underlying mechanisms are still not well understood. OBJECTIVE We examined signaling events involved in the expression of the inflammatory gene interleukin-8 (IL-8) in human airway epithelial cells (HAECs) exposed(More)
OBJECTIVE To determine factors associated with hepatic fibrosis development in people with chronic hepatitis C virus (HCV) infection. METHODS As a requirement for access to interferon therapy through the S100 scheme in Australia, individual pretreatment demographic and clinical information was collected on 2986 patients from 61 hospital-based liver(More)