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CONTEXT Exposure to ozone and particulate matter of 2.5 microm or less (PM2.5) in air at levels above current US Environmental Protection Agency (EPA) standards is a risk factor for respiratory symptoms in children with asthma. OBJECTIVE To examine simultaneous effects of ozone and PM2.5 at levels below EPA standards on daily respiratory symptoms and(More)
In a cohort of 849 infants with an asthmatic sibling, the authors examined the relations of exposure to allergens (dust mite, cockroach, cat, and dog), nitrogen dioxide, and mold with symptoms of wheeze and persistent cough in the first year of life (1998-2000). Among infants whose mothers had physician-diagnosed asthma, neither dust mite allergen nor dog(More)
This study examined the effects of indoor heating sources on infant respiratory symptoms during the heating season of the first year of life. Mothers delivering babies between 1993 and 1996 at 12 hospitals in Connecticut and Virginia were enrolled. Daily symptom and heating source use information about their infant was obtained every 2 weeks during the(More)
RATIONALE Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin. Ultrafine particles (< 0.1 microm diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 microm diameter). OBJECTIVES We compared exposure-response relationships for respiratory,(More)
BACKGROUND Reducing exposure to household dust inhalant allergens has been proposed as one strategy to reduce asthma. OBJECTIVE To examine the dose-response relationships and health impact of five common household dust allergens on disease severity, quantified using both symptom frequency and medication use, in atopic and non-atopic asthmatic children. (More)
BACKGROUND The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine with reduced serum concentrations in obese subjects. A study was undertaken to examine whether the serum adiponectin concentration is associated with human asthma and whether it explains the association between adiposity and asthma,(More)
BACKGROUND Mechanisms underlying previously reported air pollution and cardiovascular (CV) morbidity associations remain poorly understood. OBJECTIVES We examined associations between markers of pathways thought to underlie these air pollution and CV associations and ambient particle concentrations in postinfarction patients. METHODS We studied 76(More)
The relationship between ambient air pollution and daily change in peak expiratory flow (PEF) was studied in a sample of 473 nonsmoking women (age 19 to 43 yr) in Virginia over summers 1995- 1996. Daily 24-h averages of particulate matter (PM2.5 and PM10), fine particulate sulfate (SO42-) and strong acid (H+), hourly ozone (O3), and select meteorologic(More)
BACKGROUND Both increases and decreases in ambient temperature have been associated with increased cardiovascular mortality and morbidity. However, the mechanism(s) remain unclear. OBJECTIVES We examined associations between biomarkers of pathways thought to, in part, explain these associations and changes in ambient temperature in a panel of(More)