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- Robert D. Fleischmann, David Alland, +23 authors Claire M. Fraser
- Journal of bacteriology
- 2002
Virulence and immunity are poorly understood in Mycobacterium tuberculosis. We sequenced the complete genome of the M. tuberculosis clinical strain CDC1551 and performed a whole-genome comparison… (More)
- Scott B. Snapper, Rachel E. Melton, Stefan Mustafa, T. Kieser, William Robert Jacobs
- Molecular microbiology
- 1990
Recent development of vectors and methodologies to introduce recombinant DNA into members of the genus Mycobacterium has provided new approaches for investigating these important bacteria. While most… (More)
- C Kendall Stover, V. F. de la Cruz, +11 authors Barry R. Bloom
- Nature
- 1991
BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal… (More)
- Anita Banerjee, Eugenie J Dubnau, +6 authors William Robert Jacobs
- Science
- 1994
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of action on Mycobacterium tuberculosis is unknown. A missense mutation… (More)
- John D McKinney, Kerstin Hoener zu Bentrup, +7 authors David G Russell
- Nature
- 2000
Mycobacterium tuberculosis claims more human lives each year than any other bacterial pathogen. Infection is maintained in spite of acquired immunity and resists eradication by antimicrobials.… (More)
- J. Stan Cox, Bing Chen, Michael R. McNeil, William Robert Jacobs
- Nature
- 1999
Tuberculosis is the leading cause of death in the world resulting from a single bacterial infection. Despite its enormous burden on world health, little is known about the molecular mechanisms of… (More)
- Tsungda Hsu, Suzanne M. Hingley-Wilson, +14 authors William Robert Jacobs
- Proceedings of the National Academy of Sciences…
- 2003
Tuberculosis remains a leading cause of death worldwide, despite the availability of effective chemotherapy and a vaccine. Bacillus Calmette-Guérin (BCG), the tuberculosis vaccine, is an attenuated… (More)
- Vladimir Pelicic, Mary Jackson, Jean-Marc Reyrat, William Robert Jacobs, B. Gicquel, Christophe Guilhot
- Proceedings of the National Academy of Sciences…
- 1997
A better understanding of Mycobacterium tuberculosis virulence mechanisms is highly dependent on the design of efficient mutagenesis systems. A system enabling the positive selection of insertional… (More)
- Stoyan Bardarov, Svetoslav Bardarov, +6 authors William Robert Jacobs
- Microbiology
- 2002
The authors have developed a simple and highly efficient system for generating allelic exchanges in both fast- and slow-growing mycobacteria. In this procedure a gene of interest, disrupted by a… (More)
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an enzyme essential for mycolic acid biosynthesis in Mycobacterium… (More)