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- Tsungda Hsu, Suzanne M. Hingley-Wilson, +14 authors William Robert Jacobs
- Proceedings of the National Academy of Sciences…
- 2003
Tuberculosis remains a leading cause of death worldwide, despite the availability of effective chemotherapy and a vaccine. Bacillus Calmette-Guérin (BCG), the tuberculosis vaccine, is an attenuated… (More)
- Stoyan S Bardarov, Svetoslav Bardarov, +6 authors William Robert Jacobs
- Microbiology
- 2002
The authors have developed a simple and highly efficient system for generating allelic exchanges in both fast- and slow-growing mycobacteria. In this procedure a gene of interest, disrupted by a… (More)
- Marisa L. Pedulla, Michael Ford, +17 authors Graham F. Hatfull
- Cell
- 2003
Bacteriophages are the most abundant organisms in the biosphere and play major roles in the ecological balance of microbial life. The genomic sequences of ten newly isolated mycobacteriophages… (More)
- Amalio Telenti, W. Philipp, +5 authors William Robert Jacobs
- Nature Medicine
- 1997
Ethambutol (EMB), a frontline antituberculous drug, targets the mycobacterial cell wall, a unique structure among prokaryotes which consists of an outer layer of mycolic acids covalently bound to… (More)
- Joseph Hinchey, Sunhee Lee, +10 authors Steven Anthony Porcelli
- The Journal of clinical investigation
- 2007
The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium… (More)
- Miriam Braunstein, Benjamin J Espinosa, John Chan, John T. Belisle, William Robert Jacobs
- Molecular microbiology
- 2003
Tuberculosis remains a severe worldwide health threat. A thorough understanding of Mycobacterium tuberculosis pathogenesis will facilitate the development of new treatments for tuberculosis. Numerous… (More)
- Mack R Kuo, Héctor R Morbidoni, +14 authors David A. Fidock
- The Journal of biological chemistry
- 2003
Tuberculosis and malaria together result in an estimated 5 million deaths annually. The spread of multidrug resistance in the most pathogenic causative agents, Mycobacterium tuberculosis and… (More)
- Thomas R. Ioerger, Sunwoo Koo, +6 authors James C. Sacchettini
- PloS one
- 2009
The KZN strain family of Mycobacterium tuberculosis is a highly virulent strain endemic to the KwaZulu-Natal region of South Africa, which has recently experienced an outbreak of extensively-drug… (More)
- Min Yu, T. R. Santha Kumar, +26 authors David A. Fidock
- Cell host & microbe
- 2008
The fatty acid synthesis type II pathway has received considerable interest as a candidate therapeutic target in Plasmodium falciparum asexual blood-stage infections. This apicoplast-resident… (More)
- Louis J Nkrumah, Rebecca A. Muhle, +4 authors David A. Fidock
- Nature Methods
- 2006
Here we report an efficient, site-specific system of genetic integration into Plasmodium falciparum malaria parasite chromosomes. This is mediated by mycobacteriophage Bxb1 integrase, which catalyzes… (More)