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  • Yi Miao, J. L. Torres Tenor, +7 authors Richard G Brennan
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2016 (First Published: 28 June 2016)
  • Trehalose is a disaccharide essential for the survival and virulence of pathogenic fungi. The biosynthesis of trehalose requires trehalose-6-phosphate synthase, Tps1, and trehalose-6-phosphateContinue Reading
  • William R. Shadrick, Sourav Mukherjee, Alicia M Hanson, Noreena L. Sweeney, David N Frick
  • Chemistry, Medicine
  • Biochemistry
  • 2013 (First Published: 10 September 2013)
  • Aurintricarboxylic acid (ATA) is a potent inhibitor of many enzymes needed for cell and virus replication, such as polymerases, helicases, nucleases, and topoisomerases. This study examines how ATAContinue Reading
  • Megan Marie McCallum, Alan J. Pawlak, +5 authors Leggy A Arnold
  • Chemistry, Medicine
  • Analytical and Bioanalytical Chemistry
  • 2014 (First Published: 1 March 2014)
  • AbstractHerein, we describe the development of a fluorescence-based high throughput assay to determine the small molecule binding towards human serum albumin (HSA). This innovative competition assayContinue Reading
  • Jean Ndjomou, Rajesh Kolli, +8 authors David N Frick
  • Biology, Medicine
  • Antiviral research
  • 2012 (First Published: 1 November 2012)
  • The hepatitis C virus (HCV) multifunctional nonstructural protein 3 (NS3) is a protease that cleaves viral and host proteins and a helicase that separates DNA and RNA structures in reactions fueledContinue Reading