William R. Schucany

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Disagreement between the Talairach atlas and the stereotaxic space commonly used in software like SPM is a widely recognized problem. Others have proposed affine transformations to improve agreement in surface areas such as Brodmann's areas. This article proposes a similar transformation with the goal of improving agreement specifically in the deep brain(More)
We propose a test, like the classical sign test, of whether the probability of an event differs from 0.5 that is appropriate with clustered binary data. It combines a permutation approach and an exact parametric bootstrap calculation. Simulation studies show it to be superior to a sign test based on aggregated cluster level data. The new test is more(More)
Several case definitions of chronic illness in veterans of the 1991 Persian Gulf War have been linked epidemiologically with environmental exposure to cholinesterase-inhibiting chemicals, which cause chronic changes in cholinergic receptors in animal models. Twenty-one chronically ill Gulf War veterans (5 with symptom complex 1, 11 with complex 2, and 5(More)
Proportional scaling models are often used in functional imaging studies to remove confounding of local signals by global effects. It is generally assumed that global effects are uncorrelated with experimental conditions. However, when the global effect is estimated by the global signal, defined as the intracerebral average, incorrect inference may result(More)
To properly formulate functional magnetic resonance imaging (fMRI) experiments with complex mental activity, it is advantageous to permit great flexibility in the statistical components of the design of these studies. The length of an experiment, the placement of various stimuli and the modeling approach used all affect the ability to detect mental(More)
When estimating the power of genetic association studies, the allele and genotype frequencies are often assumed to be known, and the numbers of individuals with each genotype are set equal to their expectations under Hardy-Weinberg equilibrium. In fact, both allele and genotype frequencies are unknown and thus random. It has previously been suggested that(More)
In association studies of quantitative traits, the association of each genetic marker with the trait of interest is typically tested using the F-test assuming an additive genetic model. In practice, the true model is rarely known, and specifying an incorrect model can lead to a loss of power. For case-control studies, the maximum of test statistics optimal(More)
Various statistical models have been proposed to analyze fMRI data. The usual goal is to make inferences about the effects that are related to an external stimulus. The primary focus of this paper is on those statistical methods that enable one to detect 'significantly activated' regions of the brain due to event-related stimuli. Most of these methods share(More)