William R. Myers

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Gastrointestinal intolerance has been associatedwith amino bisphosphonate therapy in the clinic. Theobjective of this study was to develop a model forassessing bisphosphonateinduced gastric damage that may aid in the development of futurebisphosphonate therapies. Rats were dosed concomitantlywith indomethacin (40 mg/kg, subcutaneously) and anamino or(More)
A major problem in the analysis of clinical trials is missing data caused by patients dropping out of the study before completion. This problem can result in biased treatment comparisons and also impact the overall statistical power of the study. This paper discusses some basic issues about missing data as well as potential “watch outs.” The topic of(More)
In this paper we focus on the use of a two-stage procedure for logistic regression that emphasizes predicting response through the use of the Q-optimality criterion. The use of D-optimality in the first stage is primarily to allow best possible parameter estimates as one enters the second stage. However, it is important to understand that there are many(More)
While split-plot designs have received considerable attention in the literature over the past decade, there seems to be a general lack of intuitive understanding of the error structure of these designs and the resulting statistical analysis. Typically, students learn the proper error terms for testing factors of a split-plot design via expected mean(More)
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