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OBJECTIVE Joint hypermobility syndrome (JHS) is characterized by an association between joint hypermobility and musculoskeletal pains, the latter occurring in the absence of any objective indicator of rheumatic disease. The lack of a recognizable disease marker makes this condition difficult to identify and manage. We previously observed that patients with(More)
Iontophoretic assessment of skin microvascular function is complicated by the occurrence of electrically induced hyperaemia, especially at the cathode. Studies were performed to identify means of reducing such effects. Skin vasodilator responses were measured using a laser Doppler imager that controlled iontophoretic current delivery. A novel feature(More)
OBJECTIVES We investigated whether a session of prior exercise could ameliorate postprandial endothelial dysfunction. BACKGROUND Endothelial function is impaired after fat ingestion, and this may be related to rises in triglyceride concentrations. Exercise reduces postprandial triglyceride concentrations. METHODS Ten lean (waist <90 cm) and 10 centrally(More)
Proprioceptive sensory feedback is utilized by the central nervous system for conscious appreciation of the position and movement of the body and limbs. In patients with the hypermobility syndrome (HMS), it has been suggested that there is alteration of proprioceptive acuity. Proprioceptive performance of the knee joint was investigated in 10 female(More)
1. The present experiments were performed to resolve the discrepancy between the experiments of Boyd & Roberts (1953) in which receptors active at intermediate angles (mid range units) were frequently encountered, and the experiments of Burgess & Clark (1969) where mid range units were rarely encountered. 2. The discharge of knee joint afferents in the cat(More)
Injection of local anaesthetic into the knee joint cavity in a series of 14 cats produced obvious abnormalities of posture and gait in half the animals. However, on employing a more sensitive testing procedure, 7 out of 8 animals exhibited reduced proprioceptive acuity after knee joint anaesthesia, and all animals tested showed marked reduction in motor(More)
  • W R Ferrell
  • 1985
The effect of tetanic contraction of muscles acting at the cat knee joint on the discharge of various types of slowly adapting knee joint receptors was investigated. Contraction of a particular muscle could either increase, decrease or produce no alteration in the discharge of a given receptor. Whatever effects were produced by muscle contraction, these(More)
Obesity is increasing in prevalence worldwide and in all age groups. In nonpregnant individuals, obesity is associated with dyslipidemia; hyperinsulinemia; vascular dysfunction; and, more recently, low-grade chronic inflammation. However, whether such effects are sustained during pregnancy has been sparsely investigated but is important to establish, given(More)