Learn More
Proprioceptive sensory feedback is utilized by the central nervous system for conscious appreciation of the position and movement of the body and limbs. In patients with the hypermobility syndrome (HMS), it has been suggested that there is alteration of proprioceptive acuity. Proprioceptive performance of the knee joint was investigated in 10 female(More)
Iontophoretic assessment of skin microvascular function is complicated by the occurrence of electrically induced hyperaemia, especially at the cathode. Studies were performed to identify means of reducing such effects. Skin vasodilator responses were measured using a laser Doppler imager that controlled iontophoretic current delivery. A novel feature(More)
OBJECTIVE Joint hypermobility syndrome (JHS) is characterized by an association between joint hypermobility and musculoskeletal pains, the latter occurring in the absence of any objective indicator of rheumatic disease. The lack of a recognizable disease marker makes this condition difficult to identify and manage. We previously observed that patients with(More)
OBJECTIVES We investigated whether a session of prior exercise could ameliorate postprandial endothelial dysfunction. BACKGROUND Endothelial function is impaired after fat ingestion, and this may be related to rises in triglyceride concentrations. Exercise reduces postprandial triglyceride concentrations. METHODS Ten lean (waist <90 cm) and 10 centrally(More)
Biological therapies such as tumor necrosis factor-alpha inhibitors have advanced the treatment of rheumatoid arthritis, but one-third of patients do not respond to such therapy. Furthermore, these inhibitors are now usually administered in combination with conventional disease-modifying antirheumatic drugs, suggesting they have not achieved their early(More)
1. The present experiments were performed to resolve the discrepancy between the experiments of Boyd & Roberts (1953) in which receptors active at intermediate angles (mid range units) were frequently encountered, and the experiments of Burgess & Clark (1969) where mid range units were rarely encountered. 2. The discharge of knee joint afferents in the cat(More)
The results of this investigation demonstrate, using a position matching paradigm, that the ability of subjects to detect changes in the position of the proximal interphalangeal joint is impaired in patients with rheumatoid arthritis affecting this joint. In this group there is a systematic flexion bias in position judgements compared to an age- and(More)
Injection of local anaesthetic into the knee joint cavity in a series of 14 cats produced obvious abnormalities of posture and gait in half the animals. However, on employing a more sensitive testing procedure, 7 out of 8 animals exhibited reduced proprioceptive acuity after knee joint anaesthesia, and all animals tested showed marked reduction in motor(More)