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- L K Ziemer, S. J. W. Evans, +7 authors C. Koch
- European Journal of Nuclear Medicine and…
- 2002
Tumor hypoxia is an important prognostic indicator for cancer therapy outcome. EF5 {2-(2-nitro-1[H]-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide} has been employed to measure tumor… (More)
- William R Dolbier, Anren Li, Christof Koch, Chiounan Shiue, Alexander V. Kachur
- Applied radiation and isotopes : including data…
- 2001
There is a great deal of clinical and experimental interest in determining tissue hypoxia using non-invasive imaging methods. We have developed EF5,… (More)
- S. M. Evans, Alexander V. Kachur, +8 authors Christof Koch
- Journal of nuclear medicine : official…
- 2000
UNLABELLED
The noninvasive assessment of tumor hypoxia in vivo is under active investigation because hypoxia has been shown to be an important prognostic factor for therapy resistance. Various… (More)
- Alexander V. Kachur, William R Dolbier, +8 authors Christof Koch
- Applied radiation and isotopes : including data…
- 1999
We report on the preparation of a hypoxia marker 2-(2-nitroimidazol-1[H]-yl)-N-(3-fluoropropyl)acetamide (EF1) and its 18F analog, 2-(2-nitroimidazol-1[H]-yl)-N- (3-[18F]fluoropropyl)acetamide… (More)
- Chaya Pooput, Maurice Médebielle, William R Dolbier
- Organic letters
- 2004
[reaction: see text] A new atom-economic procedure for preparation of trifluoromethyl thio- and selenoethers is reported, wherein both halves of aryl and alkyl disulfides and diselenides are able to… (More)
- Chaya Pooput, William R Dolbier, Maurice Médebielle
- The Journal of organic chemistry
- 2006
Using a procedure analogous to that developed for nucleophilic trifluoromethylation, the perfluoroalkyl anion reagents created by mixing C2F5I and n-C4F9I with tetrakis(dimethylamino)ethylene (TDAE)… (More)
Treatment of deactivated aromatic compounds with Nbromosuccinimide in trifluoroacetic acid solvent in the presence of sulfuric acid gave the corresponding monobromoaromatic compounds in good to… (More)
- Samia Aït-Mohand, Naoto Takechi, Maurice Médebielle, William R Dolbier
- Organic letters
- 2001
A novel method for nucleophilic trifluoromethylation of aldehydes and ketones, based on photoinduced reduction of trifluoromethyl iodide by tetrakis(dimethylamino)ethylene (TDAE), is presented.… (More)
- Wei Xu, William R Dolbier
- The Journal of organic chemistry
- 2005
The nucleophilic trifluoromethylation reagent derived from CF3I and tetrakis(dimethylamino)ethylene (TDAE) was found to be effective in addition to both N-tosyl aldimines and N-tolyl sulfinimines,… (More)