William R. Bradford

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BACKGROUND Present interferon-based standard of care treatment for chronic hepatitis C virus (HCV) infection is limited by both efficacy and tolerability. We assessed the safety, tolerability, and antiviral activity of an all-oral combination treatment with two experimental anti-HCV drugs-RG7128, a nucleoside polymerase inhibitor; and danoprevir, an NS3/4A(More)
Animal heterotrimeric G proteins are activated by guanine nucleotide exchange factors (GEF), typically seven transmembrane receptors that trigger GDP release and subsequent GTP binding. In contrast, the Arabidopsis thaliana G protein (AtGPA1) rapidly activates itself without a GEF and is instead regulated by a seven transmembrane Regulator of G protein(More)
Using the Sigmoid Beverton-Holt Model we pinpoint specific effects on populations when the parameter value is varied. We will be exploring three cases in particular: δ = 1, δ < 1, and δ = 2. The real-world effects of the aformentioned cases will also be explored, specifically the " Allee Effect " which states that a population will tend towards extinction(More)
In presenting this dissertation as a partial fulfillment of the requirements for an advanced degree from Georgia State University, I agree that the Library of the University shall make it available for inspection and circulation in accordance with its regulations governing materials of this type. I agree that permission to quote from, copy from, or publish(More)
Work has always been a defining characteristic of American identity. This thesis explores the way that ideas about work in America were first expressed in literary form. Attention is paid to the work of Mather. These Puritans all wrote as the Massachusetts Bay Colony was first being discovered and developed by English settlers. Their perspective thus(More)
This study analyzes the performance of investments made by venture capital (VC) funds that specialize in financing in minority-owned businesses (MBEs). We explore the hypothesis that financing MBEs offers attractive returns to VC funds because this market niche is underserved. Traits of the VC funds – including their sources of capital and the firms they(More)
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