William Pryse-Phillips

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OBJECTIVE To identify single-nucleotide polymorphisms (SNPs) associated with risk and age at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs. DESIGN Case-control study with replication. SETTING Memory referral clinics in Canada and the United Kingdom. PARTICIPANTS The hypothesis-generating data set consisted of 753(More)
Migraine impairs physical, social and emotional functioning but the diagnosis is not always made despite the availability of helpful tools. Poor patient-physician communication is one reason cited for this. It is arguable that if the impact that headaches are having on a person's life can be communicated adequately to the physician, the likelihood of(More)
BACKGROUND Multiple sclerosis (MS) is a disease with purported environmental causes. Consistent correlations have been found in various settings for latitude, smoking exposure, sunlight, and vitamin D deficiency. We analysed the contribution of various environmental factors to the risk of developing MS from a population perspective. METHODS We collated(More)
BACKGROUND We report the case of a 58-year-old female with clinical, radiological, and histopathological evidence of Rasmussen's encephalitis, representing the oldest confirmed case to date. CASE SUMMARY The patient presented with complex partial seizures characterized by numbness of the left face and staring spells. These progressed to a state of(More)
BACKGROUND There is evidence that headache response rates may be higher if triptans are used early when a migraine attack is still mild, as compared to when it is treated after pain has reached moderate or severe intensity. METHODS In this randomized, double blind, placebo controlled, parallel group clinical trial, 361 patients took either placebo,(More)
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