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PURPOSE We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research. METHODS Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magnetic resonance microscopy (MRM) data. Cardiac and respiratory motions were modeled based on gated magnetic(More)
PURPOSE To estimate patient-specific radiation dose and cancer risk for pediatric chest computed tomography (CT) and to evaluate factors affecting dose and risk, including patient size, patient age, and scanning parameters. MATERIALS AND METHODS The institutional review board approved this study and waived informed consent. This study was HIPAA compliant.(More)
BACKGROUND Recent results from animal studies suggest that stem cells may be able to home to sites of myocardial injury to assist in tissue regeneration. However, the histological interpretation of postmortem tissue, on which many of these studies are based, has recently been widely debated. METHODS AND RESULTS With the use of the high sensitivity of a(More)
Computer models that take account of body movements promise to provide evaluation and improvement of medical imaging devices and technology. ABSTRACT | Recent work in the development of computerized phantoms has focused on the creation of ideal Bhybrid[ models that seek to combine the realism of a patient-based voxelized phantom with the flexibility of a(More)
PURPOSE To estimate organ dose from pediatric chest and abdominopelvic computed tomography (CT) examinations and evaluate the dependency of organ dose coefficients on patient size and CT scanner models. MATERIALS AND METHODS The institutional review board approved this HIPAA-compliant study and did not require informed patient consent. A validated Monte(More)
PURPOSE Current methods for estimating and reporting radiation dose from CT examinations are largely patient-generic; the body size and hence dose variation from patient to patient is not reflected. Furthermore, the current protocol designs rely on dose as a surrogate for the risk of cancer incidence, neglecting the strong dependence of risk on age and(More)
Recent studies have shown the feasibility of estimating patient dose from a CT exam using CTDI(vol)-normalized-organ dose (denoted as h), DLP-normalized-effective dose (denoted as k), and DLP-normalized-risk index (denoted as q). However, previous studies were limited to a small number of phantom models. The purpose of this work was to provide dose(More)
PURPOSE The authors develop the 4D extended cardiac-torso (XCAT) phantom for multimodality imaging research. METHODS Highly detailed whole-body anatomies for the adult male and female were defined in the XCAT using nonuniform rational B-spline (NURBS) and subdivision surfaces based on segmentation of the Visible Male and Female anatomical datasets from(More)
Respiratory motion can cause artifacts in myocardial SPECT. We incorporate respiratory mechanics into the current 4D MCAT and into the next generation spline-based MCAT phantoms. In order to simulate respiratory motion in the current MCAT phantom, the geometric solids for the diaphragm, heart, ribs, and lungs were altered through manipulation of parameters(More)
UNLABELLED Rodent species are widely used in the testing and approval of new radiopharmaceuticals, necessitating murine phantom models. As more therapy applications are being tested in animal models, calculating accurate dose estimates for the animals themselves becomes important to explain and control potential radiation toxicity or treatment efficacy.(More)