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  • S. G. Hart, William P. Beierschmitt, D. Stuart Wyand, Edward A. Khairallah, Steven D. Cohen
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1994 (First Publication: 1 June 1994)
  • Acetaminophen (APAP) administration (600 mg/kg, ip) to 18-hr-fasted, 3-month-old male CD-1 mice results in necrosis of the renal convoluted proximal tubules. To selectively inhibit APAP activation inExpand
  • John Brian Bartolone, William P. Beierschmitt, +4 authors Edward A. Khairallah
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1989 (First Publication: 1 June 1989)
  • Acetaminophen (APAP) administration (600 mg/kg, po) to fasted male CD-1 mice resulted in cellular damage to liver, lung, and kidney. An affinity purified antibody against covalently bound APAP wasExpand
    Acetaminophen (APAP) administration (600 mg/kg, po) results in proximal tubular necrosis in 18-hr fasted, 3-month-old male CD-1 mice. This study was undertaken to determine if deacetylation of APAPExpand
  • William P. Beierschmitt, John D. McNeish, Richard J. Griffiths, Atsushi Nagahisa, M. Nakane, David E. Amacher
  • Chemistry, Medicine
  • Toxicological sciences : an official journal of…
  • 2001 (First Publication: 1 September 2001)
  • The effect of 5-lipoxygenase (5-LO) inhibitors on the hepatic microsomal mixed-function oxidase (MFO) system of rodents was investigated. After establishing the relative in vitro and in vivoExpand
  • William P. Beierschmitt, John Thomas Brady, John Brian Bartolone, D. Stuart Wyand, Edward A. Khairallah, Steven D. Cohen
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1989 (First Publication: 1 May 1989)
  • Male CD-1 mice 1, 1.5, 2, and 3 months old were given 600 mg of acetaminophen (APAP)/kg, po, and liver damage was assessed 12 hr later. The most severe hepatotoxicity was in 3-month-old mice, whileExpand