William P. Moore

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To assess their attitudes toward patient input in medical decisions for breast cancer patients, 67 oncologists, 94 oncology nurses and 288 patients from a women's clinic completed the Beisecker Locus of Authority in Decision Making: Breast Cancer survey. Nurses and physicians responded in terms of a patient aged 40, 60, or 75 years. All groups believed that(More)
We have screened many synthetic and natural polymers for their ability to facilitate gene delivery in vivo into subcutaneous tissue. We postulated that gene delivery polymeric vehicles could control the chemical and biological stability of plasmid as well as their colloidal and surface properties, and this may lead to enhanced gene delivery in vivo. The(More)
Test-program generators play a key role in hardware functional verification of large scale processors. However, in the DSP domain, the usage of full-blown test-program generators is much less popular, mainly due to the limited resources (time and money) available when developing such systems. This paper describes a work-model for the fast, low cost(More)
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate cancer cell lines and xenograft models that are enzalutamide (ENZ)-responsive (C4-2) or ENZ-resistant (MR49C, MR49F). In vitro, androgen receptor(More)
Polymorphic N-acetyltransferase genes (NAT1 and NAT2) determine rapid or slow acetylation phenotypes, which are believed to affect cancer risk related to environmental exposure. Black South Africans have a unique incidence pattern of environment-related cancers, but genetic characteristics of this population are mostly unknown. In this study, we compared(More)
Fine needle aspirates (FNA) from 106 high-risk women and 25 low-risk women were evaluated for overexpression of estrogen receptor (ER), epidermal growth factor receptor (EGFR), mutant p53, and HER-2/neu by immunocytochemistry, and for aneuploidy by image analysis. Aspirates were also classified cytologically as normal, apocrine metaplasia, epithelial(More)
Breast tissue biomarkers which accurately predict breast cancer development within a 10 year period in high risk women are needed but currently not available. We initiated this study to determine 1) the prevalence of one or more breast tissue abnormalities in a group of women at high risk for breast cancer, and 2) if the prevalence of biomarker(More)
OBJECTIVE Occupational therapists frequently evaluate instrumental activities of daily living (IADL) performance with interviews and observation of simulated tasks. This study examined the congruence of judgments of independence when comparing task performance assessed by interview and simulation with task performance assessed by observation in the natural(More)