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A functional single nucleotide polymorphism (SNP) C1858T in the protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene encoding an intracellular phosphatase with negative regulatory effects on T-cell activation is associated with some autoimmune diseases in Caucasians. Taking into account firstly, that SNP frequencies may vary across populations and,(More)
INTRODUCTION Rheumatoid arthritis is an inflammatory disease driven by TH1 CD4+ cells. Interleukin-10 is present in higher concentrations in serum and synovial fluid from patients with rheumatoid arthritis and has a marked anti-inflammatory activity. Furthermore, it is capable of stimulating B cells and increasing autoantibody production. Interleukin-10(More)
OBJECTIVE Rheumatoid arthritis (RA) is considered a Th1-driven disease. Interleukin 4 (IL-4) binds to its receptor, promoting Th2 differentiation and limiting Th1 responses, but its role in the pathogenesis of RA is conflicting. We analyzed 2 polymorphisms of the IL4 gene and 4 polymorphisms of the IL4RA gene in patients with RA and in a control population,(More)
BACKGROUND The long-term effect of a PVC pipe nest-box on the reproductive efficiency and other life traits of an Aotus monkey-breeding colony have not been characterized. METHODS AND RESULTS We analyzed laboratory records of the Gorgas Memorial Institute (GMI) Aotus monkey colony in Panama for the period 1999-2010 and found a 273% increase in the annual(More)
Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have recently emerged in South-East Asia. Novel intervention strategies are therefore urgently needed to maintain the current momentum for(More)
RESUMEN Paciente de 71 años, mujer, quien presenta un cuadro clí-nico de 36 horas de dolor abdominal, asociado a hemato-quezia abundante, astenia, adinamia. Al examen físico se encuentra palidez mucocutánea generalizada y dolor a la palpación de hemiabdomen inferior, se realiza esquema diagnóstico apropiado encontrando un GIST confirmado por medio de(More)
Self-assembly of the 3-aminopropyltri-methoxysilane multilayers on Si and hysteretic current-voltage characteristics, STM investigation of large π-conjugated oligomers and tetrahydrofuran codeposited on Cu(111) by pulse injection, Electron mobility variations in surface-charged indium tin oxide thin films, Phys.
Malaria is caused by parasites of the genus Plasmodium, which are transmitted to humans by the bites of Anopheles mosquitoes. After the elimination of Plasmodium falciparum, it is predicted that Plasmodium vivax will remain an important cause of morbidity and mortality outside Africa, stressing the importance of developing a vaccine against P. vivax(More)
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