William O.C.M. Cookson

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Immunoglobulin E (IgE) is a central mediator of allergic (atopic) inflammation. Therapies directed against IgE can alleviate hay fever and allergic asthma. Genetic association studies have not yet identified novel therapeutic targets or pathways underlying IgE regulation. We therefore surveyed epigenetic associations between serum IgE concentrations and(More)
Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (>or=3024 families with >or=10 027 subjects) for(More)
Reproducibility of skin tests: a comparative study of the Pepys prick test and the Morrow-Brown needle and their correlation with the serum IgE level. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992;47:25-9. 8. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled(More)
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