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Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States
- G. Ostapowicz, R. Fontana, +12 authors William M. Lee
- Annals of Internal Medicine
- 17 December 2002
The primary aim was to compare presenting clinical features and liver transplantation in patients with acute liver failure related to acetaminophen hepatotoxicity, other drugs, indeterminate factors, and other causes. Expand
Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study
In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States, and education of patients, physicians, and pharmacies to limit high‐risk use settings is recommended. Expand
Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection.
- J. McHutchison, E. Lawitz, +17 authors M. Sulkowski
- The New England journal of medicine
- 10 December 2009
In patients infected with HCV genotype 1, the rates of sustained virologic response and tolerability did not differ significantly between theTwo available peginterferon-ribavirin regimens or between the two doses of pegin terferon alfa-2b. Expand
Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus.
In treatment-naive HCV-1 patients treated with pegylated interferon and ribavirin, a polymorphism upstream of IL-28B is associated with increased on-treatment and sustained virologic response and effectively predicts treatment outcome. Expand
ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
- N. Chalasani, P. Hayashi, H. Bonkovsky, V. Navarro, William M. Lee, R. Fontana
- The American Journal of Gastroenterology
- 1 July 2014
This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease. Expand
AASLD position paper: The management of acute liver failure
This document has been designated as a Position Paper, since the topic contains more data based on expert opinion than on randomized controlled trials and is thus not considered to have the emphasis and certainty of a Practice Guideline. Expand
Acute liver failure: Summary of a workshop
The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia, and poor prognosed with drug‐induced ALF, hepatitis B, and indeterminate cases, and excellent intensive care is critical in management of patients with ALF. Expand
Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment.
- M. Shiffman, A. D. Di Bisceglie, +11 authors J. Everhart
- Medicine, Chemistry
- 1 April 2004
BACKGROUND & AIMS The most effective therapy currently available for treatment of chronic hepatitis C virus (HCV) is the combination of peginterferon and ribavirin. This study evaluated the… Expand
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.
- Y. Loo, D. Owen, +15 authors M. Gale
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 11 April 2006
A dynamic model in which early activation of IRF-3 and induction of antiviral genes are reversed by IPS-1 proteolysis and abrogation of RIG-I signaling as NS3/4A accumulates in newly infected cells is suggested. Expand
Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.
Mortality from DILI is significantly higher in individuals with pre-existing liver disease or concomitant severe skin reactions compared with patients without, and additional studies are needed to confirm the association between azithromycin and increased DILi in patients with chronic liver disease. Expand