William List

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For the manufacture of the PCC Beriplex P/N, nanofiltration was introduced into the production process of Beriplex HS providing an additional means to heat treatment for the clearance/inactivation of viruses. By nanofiltration, large enveloped viruses (HSV-1, HIV-1) were completely eliminated by a factor of more than 7 log10. While medium-sized enveloped(More)
Pathophysiologische Grundlagen deliranter Zustandsbilder sind nach dem heutigen Stand des Wissens eher hypothetisch. Gallinat et al. beschreiben den Einfluß von Neurotransmittern, Hormonen sowie Störungen des zerebralen Metabolismus. Die Frage, ob es eine genetische Prädisposition für die Entstehung postoperativer Delirien gibt, vergleichbar etwa mit einer(More)
Recombinant human GM-CSF has been expressed as a fusion protein in E. coli in the form of inclusion bodies. Using denaturing agents, acid cleavage and sulfitolysis, the biologically inactive GM-CSF protein could be highly purified and additionally renaturated under suitable reoxidizing conditions. The thorough repair of the two disulfide bridges could be(More)
An enzyme linked immunosorbent assay (ELISA) has been developed for the quantitative determination of the most probable contaminating proteins (MCP) of recombinant human Erythropoietin produced in the mouse fibroblast cell line C-127. The developed ELISA is a double polyclonal sandwich type immunoassay, which allows a quantitation of the MCPs in the range(More)