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BACKGROUND The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone receptor (PR) status, which has(More)
OBJECTIVE To determine whether increasing calcium intake from dietary sources affects bone mineral density (BMD) and, if so, whether the effects are similar to those of calcium supplements. DESIGN Random effects meta-analysis of randomised controlled trials. DATA SOURCES Ovid Medline, Embase, Pubmed, and references from relevant systematic reviews.(More)
Traditional explanations for the popularity of auctions are efficiency and revenue maxi-mization. We argue that auctions also induce 'overbidding,' i.e., bidding above the buyer's willingness to pay for an item outside the auction. Even if only few buyers overbid, they affect prices and allocations since auctions systematically pick those buyers as winners.(More)
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