William Leung

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BACKGROUND The anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab improves outcomes in patients with node-positive HER2+ early breast cancer. Given trastuzumab's high cost, we aimed to estimate its cost-effectiveness by heterogeneity in age and estrogen receptor (ER) and progesterone receptor (PR) status, which has(More)
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance in JAK2(V617F)-negative MPN: rs12339666(More)
OBJECTIVE To determine whether increasing calcium intake from dietary sources affects bone mineral density (BMD) and, if so, whether the effects are similar to those of calcium supplements. DESIGN Random effects meta-analysis of randomised controlled trials. DATA SOURCES Ovid Medline, Embase, Pubmed, and references from relevant systematic reviews.(More)
How does job security influence productivity? I create a dataset from the bibliographic records of the National Bureau of Economic Research working paper series and from hand collected data from individual curricula vitae to compare productivity of professors before and after tenure. This paper uses a fuzzy regression discontinuity design with fixed effects(More)
Traditional explanations for the popularity of auctions are efficiency and revenue maxi-mization. We argue that auctions also induce 'overbidding,' i.e., bidding above the buyer's willingness to pay for an item outside the auction. Even if only few buyers overbid, they affect prices and allocations since auctions systematically pick those buyers as winners.(More)
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