William Lam

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miR-124-1 is a tumour suppressor microRNA (miR). Epigenetic deregulation of miRs is implicated in carcinogenesis. Promoter DNA methylation and histone modification of miR-124-1 was studied in 5 normal marrow controls, 4 lymphoma, 8 multiple myeloma (MM) cell lines, 230 diagnostic primary samples of acute myeloid leukaemia (AML), acute lymphoblastic(More)
We present a continuous time Bayesian network reasoning and learning engine (CTBN-RLE). A continuous time Bayesian network (CTBN) provides a compact (factored) description of a continuous-time Markov process. This software provides libraries and programs for most of the algorithms developed for CTBNs. For learning, CTBN-RLE implements structure and(More)
BACKGROUND The comparative efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) was recently debated. Meta-analyses, based mainly on fluoxetine comparator data, suggest that the SNRI venlafaxine has superior efficacy to SSRIs in treatment of major depression. OBJECTIVE To compare quality of(More)
Clinical trials and independent reviews support the use of cholinesterase inhibitors for treating the symptoms of patients with mild to moderate Alzheimer's disease (AD). Before initiating cholinesterase inhibitor therapy, patients should be thoroughly assessed, and the diagnosis confirmed, preferably by a specialist. Compliance with cholinesterase(More)
We consider filtering for a continuous-time, or asynchronous, stochastic system where the full distribution over states is too large to be stored or calculated. We assume that the rate matrix of the system can be compactly represented and that the belief distribution is to be approximated as a product of marginals. The essential computation is the matrix(More)
Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma (NHL). In cancers, tumor suppressive microRNAs may be silenced by DNA hypermethylation. By microRNA profiling of representative EBV-negative MCL cell lines before and after demethylation treatment, miR-155-3p was found significantly restored. Methylation-specific PCR, verified by(More)
We report the PASCAL2 benchmark for DAOOPT and GUROBI on MPE task with 330 optimally solved instances from 8 benchmark domains. DAOOPT out-performed GUROBI in 3 domains, while GUROBI was faster than DAOOPT in the rest of the 5 domains. We show that DAOOPT performed well in domains where it could have high quality initial solutions for pruning the AND/OR(More)
The paper investigates the potential of look-ahead in the context of AND/OR search in graphical models using the Mini-Bucket heuristic for combinatorial optimization tasks (e.g., MAP/MPE or weighted CSPs). We present and analyze the complexity of computing the residual (a.k.a. Bellman update) of the Mini-Bucket heuristic and show how this can be used to(More)
Best-first search can be regarded as an anytime scheme for producing lower bounds on the optimal solution, a characteristic that is mostly overlooked. In this paper we explore this topic in the context of AND/OR best-first search, guided by the mini-bucket heuristic, when solving graphical models. In that context, the impact of the secondary heuristic for(More)