• Publications
  • Influence
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2*
TLDR
This review compares and contrast PGHS-1 and -2 in the context of the regulation of expression of the two enzymes, the mechanisms of enzyme catalysis, and the biological significance of having two PGHSs. Expand
Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products*♦
TLDR
In vitro specificities of prostanoid enzymes and receptors toward EPA-derived, 3-series versus AA- derived, 2-series prostanoids substrates and products are reported and biochemical data predict that increasing phospholipid EPA/AA ratios in cells would dampen prostanoidal signaling. Expand
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.
TLDR
This chapter reviews the biochemistry and the biochemical pharmacology of the enzymes involved in the formation of prostanoids and investigates the role of phospholipase A2 and PLA2 in regulating prostanoid biosynthesis. Expand
Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.
TLDR
The concepts that COX-2 gene transcription can involve at least six different cis-acting promoter elements interacting with trans-acting factors generated by multiple, different signaling pathways are developed. Expand
Cyclooxygenases, peroxide tone and the allure of fish oil.
TLDR
There are four PGE receptor subtypes and at least one of these types--not yet identified--has a significantly different response to P GE3 than to PGE2; this difference may underlie the ability of omega3 fatty acids to mitigate inflammation and tumorigenesis. Expand
Nutritionally essential fatty acids and biologically indispensable cyclooxygenases.
TLDR
The study of cyclooxygenases (COXs), targets of aspirin and related drugs, is rooted in the discovery of essential fatty acids (EFAs), and the two COXs might have evolved partly to permit prostaglandin formation at different tissue sites. Expand
The 19-amino Acid Cassette of Cyclooxygenase-2 Mediates Entry of the Protein into the Endoplasmic Reticulum-associated Degradation System*
TLDR
Evidence is provided that the major role of the 19-AA cassette is to mediate entry of COX-2 into the ER-associated degradation system that transports ER proteins to the cytoplasm. Expand
The enzymology of prostaglandin endoperoxide H synthases-1 and -2.
TLDR
The enzymological properties of prostaglandin endoperoxide H synthases (PGHs-1 and -2) are summarized, and it is now possible to envision how arachidonate is bound and oxygenation occurs. Expand
Yes, but do they still get headaches?
TLDR
An unexpected function for the COX-2 pathway is described and a potential solution to a vitally important mystery: how does aspirin reduce the incidence of colon cancer is provided. Expand
Cyclooxygenase Allosterism, Fatty Acid-mediated Cross-talk between Monomers of Cyclooxygenase Homodimers*
TLDR
It is shown that, during catalysis, fatty acids (FAs) are bound at both COX sites of a PGHS-2 dimer, and the efficiency of AA oxygenation is determined by the nature of the FA bound to the allosteric monomer. Expand
...
1
2
3
4
5
...