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Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2*
This review compares and contrast PGHS-1 and -2 in the context of the regulation of expression of the two enzymes, the mechanisms of enzyme catalysis, and the biological significance of having two PGHSs.
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.
This chapter reviews the biochemistry and the biochemical pharmacology of the enzymes involved in the formation of prostanoids and investigates the role of phospholipase A2 and PLA2 in regulating prostanoid biosynthesis.
Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products*♦
- M. Wada, C. DeLong, William L. Smith
- Biology, Environmental ScienceJournal of Biological Chemistry
- 3 August 2007
In vitro specificities of prostanoid enzymes and receptors toward EPA-derived, 3-series versus AA- derived, 2-series prostanoids substrates and products are reported and biochemical data predict that increasing phospholipid EPA/AA ratios in cells would dampen prostanoidal signaling.
Cyclooxygenases, peroxide tone and the allure of fish oil.
- William L. Smith
- Environmental ScienceCurrent Opinion in Cell Biology
- 1 April 2005
Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.
Nutritionally essential fatty acids and biologically indispensable cyclooxygenases.
- William L. Smith
- BiologyTIBS -Trends in Biochemical Sciences. Regular ed
The 19-amino Acid Cassette of Cyclooxygenase-2 Mediates Entry of the Protein into the Endoplasmic Reticulum-associated Degradation System*
- U. Mbonye, M. Wada, C. Rieke, Huibin Tang, D. Dewitt, William L. Smith
- BiologyJournal of Biological Chemistry
- 24 November 2006
Evidence is provided that the major role of the 19-AA cassette is to mediate entry of COX-2 into the ER-associated degradation system that transports ER proteins to the cytoplasm.
Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum (*)
- A. Schievella, M. Regier, William L. Smith, Lih-Ling Lin
- Biology, Computer ScienceThe Journal of Biological Chemistry
- 22 December 1995
Immunofluorescence is used to clarify the mechanisms by which cPLA2 is regulated in intact cells and establish the nuclear envelope and endoplasmic reticulum as primary sites for the liberation of arachidonic acid in the cell.
The enzymology of prostaglandin endoperoxide H synthases-1 and -2.
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2 (*)
It appears thatPGHS-1 functions predominantly in the ER whereas PGHS-2 may function in theER and the NE, and it is speculated that PG HS-1 and PGHS -2 acting in the EMT and functioning in the NE represent independent prostanoid biosynthetic systems.