William L. Maner

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OBJECTIVE Power spectrum (PS) of uterine electromyography (EMG) can identify true labor. EMG propagation velocity (PV) to diagnose labor has not been reported. The objective was to compare uterine EMG against current methods to predict preterm delivery. STUDY DESIGN EMG was recorded in 116 patients (preterm labor, n = 20; preterm nonlabor, n = 68; term(More)
OBJECTIVE To determine whether delivery can be predicted using transabdominal uterine electromyography. METHODS A total of 99 patients were grouped as either term (37 weeks or more) or preterm (less than 37 weeks). Uterine electrical activity was recorded for 30 minutes in clinic. Electromyographic "bursts" were evaluated to determine the power density(More)
To use artificial neural networks (ANNs) on uterine electromyography (EMG) data to classify term/preterm labor/non-labor pregnant patients. A total of 134 term and 51 preterm women (all ultimately delivered spontaneously) were included. Uterine EMG was measured trans-abdominally using surface electrodes. “Bursts” of elevated uterine EMG, corresponding to(More)
Presently, there is no effective treatment for preterm labor. The most obvious reason for this anomaly is that there is no objective manner to evaluate the progression of pregnancy through steps leading to labor, either at term or preterm. Several techniques have been adopted to monitor labor, and/or to diagnose labor, but they are either subjective or(More)
In this review, we outline studies showing that the uterus (myometrium) and cervix pass through a conditioning step in preparation for labor. This step is not easily identifiable with present methods designed to assess the uterus or cervix. In the uterus, this seemingly irreversible step consists of changes in the electrical properties that make muscle more(More)
Current methodologies to assess the process of labor, such as tocodynamometry or intrauterine pressure catheters, fetal fibronectin, cervical length measurement and digital cervical examination, have several major drawbacks. They only measure the onset of labor indirectly and do not detect cellular changes characteristic of true labor. Consequently, their(More)
Diabetic gastroparesis is a disorder that predominantly affects women. However, the biological basis of this sex bias remains completely unknown. In this study we tested the hypothesis that a component of this effect may be mediated by the nitrergic inhibitory system of the enteric nervous system. Age-matched male and female Sprague-Dawley rats were studied(More)
OBJECTIVE Differentiating uterine contractions leading to preterm birth from ineffective uterine activity is difficult with current tools. Uterine electromyographic activity is recordable and consists of bursts (group of action potentials) characterized by characteristics that are different during pregnancy and labor. Our aim was to identify the chronology(More)
OBJECTIVE It has been shown that the level of soluble fms-like tyrosine kinase-1 (sFlt-1) is elevated in pregnant women who are destined to have preeclampsia, and a role for sFlt-1 in its pathogenesis has been suggested. Our objective was to determine the effect of the over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of(More)
OBJECTIVE The purpose of this study was to compare uterine electromyography of patients delivering>24 hours from measurement with laboring patients<or=24 hours from measurement. STUDY DESIGN Fifty patients (group 1: labor, n=24; group 2: antepartum, n=26) were monitored using transabdominal electrodes. Group 2 was recorded at several gestations. Uterine(More)