William Krebs

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BACKGROUND Recent reports describe discontinuation-emergent adverse events upon cessation of selective serotonin reuptake inhibitors including dizziness, insomnia, nervousness, nausea, and agitation. We hypothesized that interruption of fluoxetine treatment would be associated with fewer discontinuation-emergent adverse events than interruption of(More)
The Extreme Programming development Methodology (XP) seems appropriate for some teams or projects. Anecdotal stories from developers who have tried XP are often favorable. However, there is little empirical evidence to support or refute claims regarding XP. The Extreme Programming Evaluation Framework (XPEF) provides a benchmark measurement framework for(More)
We retrospectively examined the relationship between fluoroquinolone use and the susceptibilities of 11 bacterial pathogens to fluoroquinolones in 10 US teaching hospitals from 1991 through 2000. Statistical significance was determined by 2-way analysis of variance, with the number of isolates tested each year as a weighting factor. The analysis of(More)
Software organizations are progressively adopting the development practices associated with the Extreme Programming (XP) methodology. Most reports on the efficacy of these practices are anecdotal. This paper provides a benchmark measurement framework for researchers and practitioners to express concretely the XP practices the organization has selected to(More)
I want to turn the knobs to 10, but my job position doesn’t allow me to dictate that my team do so. Even if it did, forcing XP may serve only to cause resentment and backlash. Though I’ve been learning XP for over a year, it’s still new to the rest of our team, and we’re used to our old habits. By giving team members control of how extreme to be through a(More)
INTRODUCTION Survival from out of hospital cardiac arrest (OHCA) is highest in victims with shockable rhythms when early CPR and rapid defibrillation are provided. However, a subset of individuals present with ventricular fibrillation (VF) that does not respond to defibrillation (refractory VF). One intervention that may be a possible option in refractory(More)
The release of oil into the Gulf of Mexico (GOM) during the Deepwater Horizon event coincided with the white and pink shrimp spawning season. To determine the potential impact on shrimp larvae a series of static acute (24–96 h) toxicity studies with water accommodated fractions (WAFs) of Macondo Canyon (MC) 252 crude oil, the Corexit 9500A dispersant, and(More)