William Kessler

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OBJECTIVES The purpose of this study was to evaluate a contrast-enhanced three-dimensional (3D) breath-hold magnetic resonance (MR) technique for detection of coronary artery stenoses. BACKGROUND The accuracy of previously published MR coronary angiography protocols varies widely. Recently, coronary artery imaging using T1-shortening contrast agent has(More)
NOTICE from NOAA Mention of a commercial company or product does not constitute an endorsement by NOAA/OAR. Use of information from this publication concerning proprietary products or the tests of such products for publicity or advertising purposes is not authorized. Any opinions, findings, and conclusions or recommendations expressed in this material are(More)
A new type of freeze-drying microscope based upon time-domain optical coherence tomography is presented here (OCT-FDM). The microscope allows for real-time, in situ 3D imaging of pharmaceutical formulations in vials relevant for manufacturing processes with a lateral resolution of <7 μm and an axial resolution of <5 μm. Correlation of volumetric structural(More)
Today, most solid modeling systems are used only in the final stages of design, where iterations are driven by analysis rather than creative exploration of alternative solutions. These systems have complex interfaces, slow response, and do not provide a convenient way of specifying a three dimensional position using a two dimensional display screen. As such(More)
Recommended best practices in monitoring of product status during pharmaceutical freeze drying are presented, focusing on methods that apply to both laboratory and production scale. With respect to product temperature measurement, sources of uncertainty associated with any type of measurement probe are discussed, as well as important differences between the(More)
AIM To investigate the outcomes and recurrences of pT1b esophageal adenocarcinoma (EAC) following endoscopic mucosal resection (EMR) and associated treatments. METHODS Patients undergoing EMR with pathologically confirmed T1b EAC at two academic referral centers were retrospectively identified. Patients were divided into 4 groups based on treatment(More)