William K. Nichols

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We treated human lung epithelial cells, type BEAS-2B, with 10-80 microg/cm2 of dust from soils and road surfaces in the western United States that contained particulate matter (PM) < 2.5 microm aerodynamic diameter. Cell viability and cytokine secretion responses were measured at 24 hr. Each dust sample is a complex mixture containing particles from(More)
In previous reports, methamphetamine was shown to depress tyrosine hydroxylase (TH) activity in the rat corpus striatum. To evaluate further the mechanism of this decrease in TH activity, enzyme activity was measured in the rat corpus striatum and substantia nigra after repetitive and single-dose methamphetamine administration. Following repeated doses of(More)
Thrombocytopenia was associated with the presence of heparin-coated pulmonary artery catheters in 12 patients with heparin-associated antiplatelet antibodies. The thrombocytopenia persisted so long as the heparin-coated catheters were in place, even when all other sources of heparin were discontinued. The high morbidity and mortality associated with(More)
A new method of treatment of spondyloptosis is presented utilizing a staged approach. The first stage consists of a vertebral body resection of L5 along with the L4-5 and L5-S1 discs. The second stage procedure consists of removal of the loose posterior element, the articular processes, and pedicles of L5 and reduction of L4 onto the sacrum. The technique(More)
Fifty-one male and two female patients were divided into the following three groups: (a) patients with symptomatic carotid artery disease who received carotid endarterectomies, (b) patients with symptomatic carotid artery disease who either declined or were not candidates for carotid endarterectomies, and (c) patients who received a surgical procedure(More)
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