William K. Fant

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Results of a randomized trial comparing imipenem/cilastatin versus the combination of gentamicin plus clindamycin for mixed flora surgical sepsis are reported herein. Seventy-four patients were evaluable, 50 of whom had intra-abdominal sepsis. No imipenem-resistant initially infecting isolates were encountered. When outcome was evaluated on the basis of(More)
The potential for justifying the cost of a part-time clinical pharmacist position was evaluated. Patients in the medical and surgical intensive-care units of a community hospital were monitored two hours per day for 32 weekdays by a part-time staff pharmacist. The pharmacist completed an initial review of the charts of all patients newly admitted to the(More)
The University of Cincinnati (UC) has been active in the National Library of Medicine's Integrated Advanced Information Management Systems (IAIMS) program since IAIMS' inception in 1984. UC received IAIMS planning and modeling grants in the 1980s, spent the 1990s practicing its own form of "iaims" and refining its vision, and, in May 2003, received an IAIMS(More)
10 psychiatric inpatients with a diagnosis of depression were entered into a prospective study to investigate the repeated one-point method as a method of predicting steady-state concentrations for nortriptyline. Four males and 4 females completed all requirements of the protocol. Single plasma concentrations obtained after the first and second daily doses(More)
Vanderbush RE, Anderson HG, Fant WK, et al. Implementing pharmacy informatics in college curricula: The AACP technology in pharmacy education and learning special interest group. Abstract Many professional organizations have initiatives to increase the awareness and use of informatics in the practice of pharmacy. Within education we must respond to these(More)
  • W K Fant
  • 1990
The role of the pharmacist in defining and implementing criteria for selection of patients who are most likely to benefit from monoclonal antibody therapy is discussed. The introduction of new biotechnology products has raised concerns about rationing of health-care services, particularly in view of the costs of drug research and development. Traditional(More)
Eleven healthy males between 21 and 37 years of age were enrolled into a non-randomized crossover study comparing superactive charcoal (SAC) given after ethanol administration. After receiving 0.6 gm/kg ethanol orally (95% V/V diluted in orange juice), blood was sampled at 0, 0.5, 1.0, 1.5, 2.0, 3.0, and 4.0 hours. Area under the curve (AUC) was calculated(More)
The diverse needs of students, faculty, administrators, and the curriculum itself, create formidable challenges when attempting to integrate mobile technology into a health professions curriculum. Single technology solutions often fail in this environment because they cannot meet user needs. Multiple platform and device agnostic solutions can provide the(More)
Many professional organizations have initiatives to increase the awareness and use of informatics in the practice of pharmacy. Within education we must respond to these initiatives and make technology integral to all aspects of the curriculum, inculcating in students the importance of technology in practice. This document proposes 5 central domains for(More)
This study was designed to determine the effectiveness of clonidine (CL) and CL analogue, lofexidine (LF), in reducing the incidence and/or severity of convulsion associated with barbiturate withdrawal in mice. CL and LF have been shown to be useful in blocking opioid withdrawal symptoms in rodents and man. Some of the symptoms and possibly the mechanism(s)(More)