William K. Chan

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BACKGROUND Teenage male drivers contribute to a large number of serious road crashes despite low rates of driving and excellent physical health. We examined the amount of road trauma involving teenage male youth that might be explained by prior disruptive behavior disorders (attention deficit hyperactivity disorder, conduct disorder, oppositional defiant(More)
The tremendous therapeutic potential of peptides has not yet been realized, mainly owing to their short in vivo half-life. Although conjugation to macromolecules has been a mainstay approach for enhancing protein half-life, the steric hindrance of macromolecules often harms the binding of peptides to target receptors, compromising the in vivo efficacy. Here(More)
BACKGROUND Human error due to risky behaviour is a common and important contributor to acute injury related to poverty. We studied whether social benefit payments mitigate or exacerbate risky behaviours that lead to emergency visits for acute injury among low-income mothers with dependent children. METHODS We analyzed total emergency department visits(More)
The aryl hydrocarbon receptor (AhR) is a transcription factor that induces the adaptive responses upon binding to a wide range of exogenous chemicals in cells. The traditional method for studying AhR ligands is to determine their effect on transcriptional activities (e.g., luciferase expression) in cultured cells. In this paper, we sought to investigate the(More)
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