William Joseph Dupps

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PURPOSE To elucidate the phenotypic and biochemical characteristics of a novel mutation associated with autosomal dominant cone-rod dystrophy (adCORD). METHODS Twenty-three family members of a CORD pedigree underwent clinical examinations, including visual acuity tests, standardized full-field ERG, and fundus photography. Genomic DNA was screened for(More)
The biomechanical and wound healing properties of the cornea undermine the predictability and stability of refractive surgery and contribute to discrepancies between attempted and achieved visual outcomes after LASIK, surface ablation and other keratorefractive procedures. Furthermore, patients predisposed to biomechanical failure or abnormal wound healing(More)
PURPOSE To evaluate visual acuity, refractive outcomes, and endothelial cell density 6 months after Descemet stripping and automated endothelial keratoplasty (DSAEK). METHODS We performed an institutional review board-approved prospective study of a surgical case series of 34 patients at 2 institutions undergoing DSAEK for Fuchs endothelial dystrophy,(More)
PURPOSE To theoretically compare the corneal stress distribution of laser in situ keratomileusis (LASIK) with the stress distribution of small-incision lenticule extraction. SETTING Cleveland Clinic Cole Institute, Cleveland, and The Ohio State University, Columbus, Ohio, USA. DESIGN Computational modeling study. METHODS A finite-element anisotropic(More)
PURPOSE To examine early postoperative wound healing in rabbit corneas that had LASIK flaps formed with three different models (15 KHz, 30 KhZ, and 60 KHz) of a femtosecond laser compared with flaps formed with a microkeratome. METHODS Thirty-nine rabbit eyes were randomized to receive either no surgery or corneal flaps formed with one of the lasers or(More)
The aim of this study was to investigate the relationship between the level of stromal surface irregularity after photorefractive keratectomy (PRK) and myofibroblast generation along with the development of corneal haze. Variable levels of stromal surface irregularity were generated in rabbit corneas by positioning a fine mesh screen in the path of excimer(More)
PURPOSE To describe pachymetric progression indices (PPI) of the Pentacam HR (Oculus Optikgeräte GmbH) and the concept of relational thickness, and to test their accuracy for differentiating keratoconic and normal corneas compared with single-point thickness values. METHODS One hundred thirteen individual eyes randomly selected from 113 normal patients(More)
IMPORTANCE Optical coherence tomography (OCT) has transformed the clinical management of a myriad of ophthalmic conditions. Applying OCT to ophthalmic surgery may have implications for surgical decision making and patient outcomes. OBJECTIVE To assess the feasibility and effect on surgical decision making of a microscope-integrated intraoperative OCT(More)
Schnyder crystalline corneal dystrophy (SCCD) is a rare autosomal dominant disease characterized by progressive corneal opacification resulting from abnormal deposition of cholesterol and phospholipids. Recently, six different mutations on the UBIAD1 gene on chromosome 1p36 were found to result in SCCD. The purpose of this article is to further characterize(More)
A critical element of peer-reviewed publication is clear communication to the reader and the ophthalmic and medical community. Refractive surgery has the luxury of multiple procedures with multiple outcome parameters that are relevant to clinicians, researchers, and, of course, patients. This diversity introduces complexity for the reader in evaluating and(More)