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Recent studies on the agreement and correlation between measured and calculated total CO2 (TCO2) have yielded conflicting results. Pre-analytical variation could have been partially responsible. While keeping such variables at an absolute minimum, we found excellent correlation (r = 0.98) in 88 samples, with only a small variation in agreement between(More)
Human adenosine deaminase (ADA; EC consists of three isoenzymes: ADA1, ADA1+CP, and ADA2. We developed an electrophoretic technique to distinguish between these three isoenzymes. The isoenzyme pattern was studied in tissue and cell homogenates, as well as in serum from normal subjects and from patients with increased serum ADA who had either(More)
BACKGROUND B-type natriuretic peptide (BNP) and the inactive amino-terminal pro-B-type natriuretic peptide (NTproBNP) have a prognostic value in heart failure and in myocardial infarction. There has been some evidence that BNP and NT-proBNP can be used in the diagnosis of myocardial ischaemia by improving the sensitivity of exercise- stress testing. (More)
The frequency of the euthyroid sick syndrome (ESS) was assessed in 3444 hospital patients. For the first 6 months the free thyroxine index (FTI) was used: 3.6% of 1674 patients had ESS compared with 17.3% of 1770 in the second 6 months diagnosed by a direct free thyroxine (FT4) assay ("Amerlex'). The relative frequencies of each type of ESS (low(More)
BACKGROUND Amino terminal pro-B-type natriuretic peptide (NT-proBNP) is a sensitive marker of ventricular dysfunction. Exercise causes an increase in the secretion of NTproBNP, and with myocardial ischaemia the increase is more pronounced. This increase has been found to improve the diagnostic sensitivity of the stress ECG in diagnosing myocardial ischaemia(More)
The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus). The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d)(More)
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