William J. Henzel

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Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Hua Song Zou, William J. Henzel, Xuesong Liu, Alexis Lutschg, Xiaodong Wang
Cell
1997

We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in the cytochrome c-dependent activation of caspase-3. The NH2-terminal 85… (More)

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells.

Napoleone M. A. Ferrara, William J. Henzel
Biochemical and biophysical research…
1989

A growth factor for vascular endothelial cells was identified in the media conditioned by bovine pituitary follicular cells and purified to homogeneity by a combination of ammonium sulfate… (More)

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

Joe D. Lewis, Richard R. Meehan, +4 authors Adrian Bird
Cell
1992

Methylation of mammalian DNA can lead to repression of transcription and alteration of chromatin structure. Recent evidence suggests that both effects are the result of an interaction between the… (More)

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

Mike Rothe, M D Pan, William J. Henzel, T M Ayres, David V. Goeddel
Cell
1995

The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and… (More)

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

Mike Rothe, Suzy C. Wong, William J. Henzel, David V. Goeddel
Cell
1994

Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmic domain of the human 75 kDa tumor necrosis factor receptor (TNF-R2) that is required for signal… (More)

IRAK: a kinase associated with the interleukin-1 receptor.

Zhaodan Cao, William J. Henzel, Xiong Zhuo Gao
Science
1996

The pleiotropic biological activities of interleukin-1 (IL-1) are mediated by its type I receptor (IL-1RI). When the ligand binds, IL-1RI initiates a signaling cascade that results in the activation… (More)

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

Holger Wesche, William J. Henzel, W Shillinglaw, Shao-ping Li, Zhaodan Cao
Immunity
1997

IL-1 is a proinflammatory cytokine that signals through a receptor complex of two different transmembrane chains to generate multiple cellular responses, including activation of the transcription… (More)

Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz

James E. Wilhelm, Meredith Hilton, Quinlan Amos, William J. Henzel
The Journal of cell biology
2003

In Drosophila oocytes, precise localization of the posterior determinant, Oskar, is required for posterior patterning. This precision is accomplished by a localization-dependent translational control… (More)

An interleukin-4-induced transcription factor: IL-4 Stat.

Jingwen Hou, Ulrike Schindler, William J. Henzel, Tony Cheong-Yip Ho, M. Bourdon-Le Brasseur, Steven L. McKnight
Science
1994

Interleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell… (More)

Growth hormone receptor and serum binding protein: purification, cloning and expression

David W. M. Leung, Steven A. Spencer, +6 authors William I. Wood
Nature
1987

A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same ammo-terminal amino-acid sequence, indicating that the binding protein… (More)

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