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We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in the cytochrome c-dependent activation of caspase-3. The NH2-terminal 85… (More)
- Mike Rothe, M D Pan, William J. Henzel, T M Ayres, David V. Goeddel
- Cell
- 1995
The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and… (More)
- Joe D. Lewis, Richard R. Meehan, +4 authors Adrian Bird
- Cell
- 1992
Methylation of mammalian DNA can lead to repression of transcription and alteration of chromatin structure. Recent evidence suggests that both effects are the result of an interaction between the… (More)
- Napoleone M. A. Ferrara, William J. Henzel
- Biochemical and biophysical research…
- 1989
A growth factor for vascular endothelial cells was identified in the media conditioned by bovine pituitary follicular cells and purified to homogeneity by a combination of ammonium sulfate… (More)
- Mike Rothe, Suzy C. Wong, William J. Henzel, David V. Goeddel
- Cell
- 1994
Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmic domain of the human 75 kDa tumor necrosis factor receptor (TNF-R2) that is required for signal… (More)
- Holger Wesche, William J. Henzel, W Shillinglaw, Shao-ping Li, Zhaodan Cao
- Immunity
- 1997
IL-1 is a proinflammatory cytokine that signals through a receptor complex of two different transmembrane chains to generate multiple cellular responses, including activation of the transcription… (More)
- Zhaodan Cao, William J. Henzel, Xiong Zhuo Gao
- Science
- 1996
The pleiotropic biological activities of interleukin-1 (IL-1) are mediated by its type I receptor (IL-1RI). When the ligand binds, IL-1RI initiates a signaling cascade that results in the activation… (More)
Interleukin-4 (IL-4) is an immunomodulatory cytokine secreted by activated T lymphocytes, basophils, and mast cells. It plays an important role in modulating the balance of T helper (Th) cell… (More)
- Alexander M Dizhoor, Elena V. Olshevskaya, +4 authors James B Hurley
- The Journal of biological chemistry
- 1995
Two vertebrate photoreceptor-specific membrane guanylyl cyclases, RetGC-1 and RetGC-2, are activated by a soluble 24-kDa retinal protein, p24, in a Ca(2+)-sensitive manner (Dizhoor, A.M., Lowe, D.G.,… (More)
- James E. Wilhelm, Meredith Hilton, Quinlan Amos, William J. Henzel
- The Journal of cell biology
- 2003
In Drosophila oocytes, precise localization of the posterior determinant, Oskar, is required for posterior patterning. This precision is accomplished by a localization-dependent translational control… (More)